[CAS NO. 839712-15-1] Desmethyl cariprazine

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PRODUCTS SPECIFICATIONS [839712-15-1]

Catalog

HY-100656

Brand

MCE

CAS

839712-15-1

DESCRIPTION [839712-15-1]

Overview

MDL	-
Molecular Weight	413.38
Molecular Formula	C20H30Cl2N4O
SMILES	O=C(NC)N[C@@H]1CC[C@@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1

For research use only. We do not sell to patients.

Summary

Desmethyl cariprazine is an active metabolite of Cariprazine ^[1] . Cariprazine, an antipsychotic drug candidate, exhibits high affinity for the D3 (K _i =0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM) ^[2] .

IC50 & Target

D ₃ Receptor

0.085 nM (Ki)

D ₂ Receptor

0.49 nM (Ki)

5-HT _1A Receptor

2.6 nM (Ki)

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 12.10 mM ; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4191 mL	12.0954 mL	24.1908 mL
5 mM	0.4838 mL	2.4191 mL	4.8382 mL
10 mM	0.2419 mL	1.2095 mL	2.4191 mL

* Please refer to the solubility information to select the appropriate solvent.