[CAS NO. 85-79-0] Dibucaine
PRODUCTS SPECIFICATIONS [85-79-0]
DESCRIPTION [85-79-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 343.46 |
| Molecular Formula | C20H29N3O2 |
| SMILES | O=C(C1=CC(OCCCC)=NC2=CC=CC=C12)NCCN(CC)CC |
2 Publications Citing Use of MCE
Summary
Dibucaine (Cinchocaine) is a sodium channel inhibitor. Dibucaine is a potent SChE inhibitor [1] [2] .
In Vitro
Dibucaine (Cinchocaine) reduces the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain [1] . Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 36 mg/mL ( 104.82 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9115 mL | 14.5577 mL | 29.1155 mL |
| 5 mM | 0.5823 mL | 2.9115 mL | 5.8231 mL |
| 10 mM | 0.2912 mL | 1.4558 mL | 2.9115 mL |
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1.
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution
References
Synonyms