[CAS NO. 851305-26-5] LJ001

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [851305-26-5]

Catalog

HY-16957

Brand

MCE

CAS

851305-26-5

DESCRIPTION [851305-26-5]

Overview

MDL	-
Molecular Weight	327.42
Molecular Formula	C17H13NO2S2
SMILES	S=C(N(CC=C)C/1=O)SC1=C/C(O2)=CC=C2C3=CC=CC=C3

For research use only. We do not sell to patients.

Summary

LJ001 is a broad-spectrum and orally active antiviral agent. LJ001 exerts antiviral activities by binding to viral membranes. LJ001 inhibits TGEV and PDCoV infection . LJ001 decreases TGEV N and PDCoV N-protein expression ^[1] ^[2] .

In Vitro

LJ001 (0.782- 200 μM; 24 h) shows no significant cytotoxicity with a CC ₅₀ value of 146.4 μM for ST cells ^[1] .
LJ001 (12.5 µM; 12, 24 h) inhibits transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) infection ^[1] .
LJ001 (12.5 µM; 1, 6,12, 24 h) decreases the TGEV and PDCoV gene mRNA expression in ST cells ^[1] .
LJ001 can inhibit the entry and spread of some enveloped viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza, Ebola, arenaviruses and poxvi ruses ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	ST cells
Concentration:	0.782, 1.563, 3.125, 6.25, 12.5, 25, 50, 100, 200 μM
Incubation Time:	24 h
Result:	Showed slight cytotoxicity with a CC ₅₀ value of 146.4 μM.

Western Blot Analysis ^[1]

Cell Line:	ST cells
Concentration:	12.5 µM
Incubation Time:	12, 24 h
Result:	Decreased the expression of TGEV N protein and PDCoV N-protein at 24 h and markedly reduced TCID ₅₀ titers at 12 and 24 h.

RT-PCR ^[1]

Cell Line:	ST cells
Concentration:	12.5 µM
Incubation Time:	1, 6, 12, 24 h
Result:	Inhibited TGEV and PDCoV gene mRNA expression in a time-dependent manner.

In Vivo

LJ001 (20, 50 mg/kg; oral gavage or i.p.; daily for 7 days) shows no toxicity in mouse ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c mice ^[2]
Dosage:	20, 50 mg/kg
Administration:	Oral gavage or i.p.; daily for 7 days
Result:	Revealed no abnormalities except a slight elevation in serum cholesterol levels in the treated vs. vehicle control group.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.