[CAS NO. 852391-15-2] Necrostatin2racemate
PRODUCTS SPECIFICATIONS [852391-15-2]
DESCRIPTION [852391-15-2]
Overview
| MDL | MFCD26743828 |
|---|---|
| Molecular Weight | 277.71 |
| Molecular Formula | C13H12ClN3O2 |
| SMILES | ClC1=C2C(C(CC3C(N(C)C(N3)=O)=O)=CN2)=CC=C1 |
5 Publications Citing Use of MCE
Summary
Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect [1] .
IC50 & Target
|
RIPK1 |
In Vitro
Necrostatin 2 racemate (Nec-1S) (1-100 μM; 1 h) potently inhibits RIPK1 autophosphorylation in a dose-dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Necrostatin 2 racemate (Nec-1S) (6 mg/kg; i.v.; once) protects against TNF-induced systemic inflammatory response syndrome (SIRS) without sensitization effect [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Female C57BL/6J WT mice, SIRS model [1] |
| Dosage: | 0.6 mg/kg or 6 mg/kg |
| Administration: | Intravenous injection, once |
| Result: | Showed protective effect at 6 mg/kg. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 180.04 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6009 mL | 18.0044 mL | 36.0088 mL |
| 5 mM | 0.7202 mL | 3.6009 mL | 7.2018 mL |
| 10 mM | 0.3601 mL | 1.8004 mL | 3.6009 mL |