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[CAS NO. 857652-30-3] PSN632408
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-16673 |
| Brand: | MCE |
| CAS: | 857652-30-3 |
Overview
| MDL | MFCD09297322 |
|---|---|
| Molecular Weight | 360.41 |
| Molecular Formula | C18H24N4O4 |
| SMILES | O=C(OC(C)(C)C)N1CCC(CC1)OCC2=NC(C3=CC=NC=C3)=NO2 |
Summary
PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors ( EC 50 =5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders [1] [2] .
In Vitro
In Vivo
PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Diet-induced obese (DIO) rats [1] |
| Dosage: | 100 mg/kg |
| Administration: | P.o.; daily for 14 days |
| Result: | The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 138.73 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7746 mL | 13.8731 mL | 27.7462 mL |
| 5 mM | 0.5549 mL | 2.7746 mL | 5.5492 mL |
| 10 mM | 0.2775 mL | 1.3873 mL | 2.7746 mL |
References
- [1] Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175.
- [2] Gao J, et al. Stimulating beta cell replication and improving islet graft function by GPR119 agonists. Transpl Int. 2011;24(11):1124-1134.
Synonyms
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