[CAS NO. 857652-30-3] PSN632408

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PRODUCTS SPECIFICATIONS [857652-30-3]

Catalog

HY-16673

Brand

MCE

CAS

857652-30-3

DESCRIPTION [857652-30-3]

Overview

MDL	MFCD09297322
Molecular Weight	360.41
Molecular Formula	C18H24N4O4
SMILES	O=C(OC(C)(C)C)N1CCC(CC1)OCC2=NC(C3=CC=NC=C3)=NO2

For research use only. We do not sell to patients.

Summary

PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors ( EC ₅₀ =5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders ^[1] ^[2] .

In Vitro

PSN632408 produces concentration-dependent increases in cAMP level with mean EC ₅₀ value of 1.9 uM ^[1] .
PSN632408 stimulates β cell replication in cultured mouse islets ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Diet-induced obese (DIO) rats ^[1]
Dosage:	100 mg/kg
Administration:	P.o.; daily for 14 days
Result:	The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 138.73 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7746 mL	13.8731 mL	27.7462 mL
5 mM	0.5549 mL	2.7746 mL	5.5492 mL
10 mM	0.2775 mL	1.3873 mL	2.7746 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1-Piperidinecarboxylic acid, 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-, 1,1-dimethylethyl ester

1,1-Dimethylethyl 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-1-piperidinecarboxylate

PSN 632408