[CAS NO. 859518-94-8] T0467
PRODUCTS SPECIFICATIONS [859518-94-8]
DESCRIPTION [859518-94-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 441.49 |
| Molecular Formula | C24H26F3N5 |
| SMILES | FC1=CC=C(CN2[C@H](CNCC2)C)C=C1C3=NC(NCCC4=CC(F)=CC(F)=C4)=NC=C3 |
Summary
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro . T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research [1] .
In Vitro
T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells
[1]
. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells
[1]
.
T0467 does not show obvious toxicity in
Drosophila
at concentrations <50 μM. All cpds examined mitigated the PINK1 inactivation-mediated larval locomotion defects and mitochondrial morphological defects and reduced ATP production. T0467 and KTP improved the mitochondrial Ca
2+
response in
Drosophila
larval muscles
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 33.33 mg/mL ( 75.49 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2651 mL | 11.3253 mL | 22.6506 mL |
| 5 mM | 0.4530 mL | 2.2651 mL | 4.5301 mL |
| 10 mM | 0.2265 mL | 1.1325 mL | 2.2651 mL |
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1.