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[CAS NO. 861139-16-4] RSV-IN-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-112673 |
| Brand: | MCE |
| CAS: | 861139-16-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 427.48 |
| Molecular Formula | C20H21N5O4S |
| SMILES | O=S(C1=CC=C(OC)C(C2=NN=C3N2N=C(C)C4=C3C=CC=C4)=C1)(N(CCO)C)=O |
Summary
RSV-IN-1 is a human respiratory syncytical virus (hRSV) inhibitor, with an IC 50 of 0.11 μM.
IC50 & Target
IC50: 0.11μM (hRSV) [1] .
In Vitro
The concentration of P13 that reduces the number of RSV plaques in HEp-2 cells by 50% (IC 50 ) is 0.11 μM. The concentration of P13 that reduces the viability of HEp-2 by 50% (CC 50 ) is 310 μM. Note that some cytotoxicity of P13 observed at 500 μM might be due to DMSO solvent. Hence, the selective index (CC 50 /IC 50 ) values is 2818 for P13. Note that even at the relatively high concentrations P13 does not completely block the development of RSV plaques. These escape plaques are of smaller size and of non-syncytial phenotype as compared to plaques formed in the absence of inhibitor [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 233.93 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3393 mL | 11.6965 mL | 23.3929 mL |
| 5 mM | 0.4679 mL | 2.3393 mL | 4.6786 mL |
| 10 mM | 0.2339 mL | 1.1696 mL | 2.3393 mL |
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