[CAS NO. 861891-50-1] IM-54

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PRODUCTS SPECIFICATIONS [861891-50-1]

Catalog

HY-108351

Brand

MCE

CAS

861891-50-1

DESCRIPTION [861891-50-1]

Overview

MDL	-
Molecular Weight	325.40
Molecular Formula	C19H23N3O2
SMILES	O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3NCCCCC)N(C)C3=O

For research use only. We do not sell to patients.

Summary

IM-54 is a selective inhibitor of oxidative stress-induced necrosis . IM-54 shows potent inhibitory activity against H ₂ O ₂ -induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death ^[1] ^[2] .

In Vitro

IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis ^[1] .
IM-54 shows strong inhibition of H ₂ O ₂ -induced necrosis, with an IC ₅₀ of 0.25 μM in HL-60 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 153.66 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0731 mL	15.3657 mL	30.7314 mL
5 mM	0.6146 mL	3.0731 mL	6.1463 mL
10 mM	0.3073 mL	1.5366 mL	3.0731 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (7.68 mM); Clear solution

* All of the co-solvents are available by MCE.