[CAS NO. 863329-66-2] PSI-6206

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PRODUCTS SPECIFICATIONS [863329-66-2]

Catalog

HY-15236

Brand

MCE

CAS

863329-66-2

DESCRIPTION [863329-66-2]

Overview

MDL	MFCD19982668
Molecular Weight	260.22
Molecular Formula	C10H13FN2O5
SMILES	O=C(C=CN1[C@H]2[C@@](F)(C)[C@H](O)[C@@H](CO)O2)NC1=O

For research use only. We do not sell to patients.

3 Publications Citing Use of MCE

Summary

PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC ₉₀ of >100 μM.

IC50 & Target

EC90：>100 μM (HCV replicon) ^[1]

In Vitro

PSI-6206 (RO 2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay ^[1] . The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B ^[2] . PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 384.29 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8429 mL	19.2145 mL	38.4290 mL
5 mM	0.7686 mL	3.8429 mL	7.6858 mL
10 mM	0.3843 mL	1.9215 mL	3.8429 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Uridine, 2′-deoxy-2′-fluoro-2′-methyl-, (2′R)-

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine

RO 2433

PSI-6206

GS 331007

1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

(2′R)-2′-Deoxy-2′-fluoro-2′-methyluridine