[CAS NO. 867257-26-9] Tecarfarin

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PRODUCTS SPECIFICATIONS [867257-26-9]

Catalog

HY-14854

Brand

MCE

CAS

867257-26-9

DESCRIPTION [867257-26-9]

Overview

MDL	-
Molecular Weight	460.32
Molecular Formula	C21H14F6O5
SMILES	O=C(OC(C(F)(F)F)(C)C(F)(F)F)C1=CC=C(CC2=C(O)C3=CC=CC=C3OC2=O)C=C1

For research use only. We do not sell to patients.

Summary

Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase ( VKOR ) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X ^[1] . Tecarfarin has the antithrombotic activity ^[2] .

IC50 & Target

VKOR ^[1]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00691470	ARYx Therapeutics	Atrial Fibrillation\|Atrial Flutter\|Venous Thromboembolic Disease\|Myocardial Infarction\|Cardiomyopathy	May 2008	Phase 2\|Phase 3
NCT02522221	Espero Biopharma	Thromboembolism\|Thrombosis	June 1, 2018	Phase 3
NCT04627116	Lee´s Pharmaceutical Limited	Healthy Chinese Volunteers	April 19, 2020	Phase 1
NCT00431782	ARYx Therapeutics	Atrial Fibrillation	December 2006	Phase 2
NCT03652779	Lee´s Pharmaceutical Limited	Pharmacokinetic and Pharmacodynamic Profile of Tecarfarin	June 22, 2018	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 543.10 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1724 mL	10.8620 mL	21.7240 mL
5 mM	0.4345 mL	2.1724 mL	4.3448 mL
10 mM	0.2172 mL	1.0862 mL	2.1724 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.52 mM); Clear solution

* All of the co-solvents are available by MCE.