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[CAS NO. 87-44-5] β-Caryophyllene
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N1415 |
| Brand: | MCE |
| CAS: | 87-44-5 |
Overview
| MDL | MFCD00075925 |
|---|---|
| Molecular Weight | 204.35 |
| Molecular Formula | C15H24 |
| SMILES | C=C1CC/C=C(C)/CC[C@@]2([H])C(C)(C)C[C@]12[H] |
Summary
β-Caryophyllene is a CB2 receptor agonist.
IC50 & Target
CB2 receptor [1]
In Vitro
Among the tested cancer cells, β-Caryophyllene demonstrates selective anti-proliferative effect against three cancer cell lines, namely HCT 116 (colon cancer, IC 50 =19 μM), PANC-1 (pancreatic cancer, IC 50 =27 μM), and HT29 (colon cancer, IC 50 =63 μM) cells, whereas β-Caryophyllene exhibits either moderate or poor cytotoxic effects against ME-180, PC3, K562 and MCF-7. Results show that β-Caryophyllene possesses higher selectivity towards the colorectal cancer cells (HCT 116), with selectivity index (SI)=27.9, followed by PANC-1 and HT 29 cells with SI=19.6 and 8, respectively. The apoptotic index estimated for β-Caryophyllene treatment on HCT 116 cells after 24 h treatment is 64±0.04. β-Caryophyllene at 10 μM concentration, causes significant nuclei condensation after 6 h of treatment. β-caryophyllene exhibits a dose and time-dependent inhibitory effect on the motility of HCT 116 cells [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Treatment with β-Caryophyllene at different doses does not show any effects on swimming speed during the test. Oral treatment with β-Caryophyllene ameliorates the rise in β-amyloid deposition in the transgenic mice in a roughly dose-dependent manner, and the two higher doses exhibit almost equal effects in modifying the β-amyloid burden. The number of activated astroglial cells is higher in vehicle-treated mouse brains than in β-Caryophyllene-treated mouse brains with different doses. β-Caryophyllene is effective at reducing the enhancement of the COX-2 protein level found in vehicle-treated APP/PS1 mice [1] . Animals treated with β-Caryophyllene display higher values of object recognition index than their vehicle-treated counterparts [t(14)=4.204, P<0.05]. The total time spent in object exploration during the test trial is not significantly different between β-Caryophyllene-treated and vehicle-treated animals (t(14)=0.5874, P>0.05). Treatment with β-Caryophyllene does not significantly alter these seizure-induced neurochemical changes [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
Ethanol : ≥ 176.67 mg/mL ( 864.55 mM )
DMSO : 50 mg/mL ( 244.68 mM ; ultrasonic and warming and heat to 60°C)
H 2 O : 0.67 mg/mL ( 3.28 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.8936 mL | 24.4678 mL | 48.9356 mL |
| 5 mM | 0.9787 mL | 4.8936 mL | 9.7871 mL |
| 10 mM | 0.4894 mL | 2.4468 mL | 4.8936 mL |
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1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (489.36 mM); Clear solution; Need ultrasonic
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2.
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3.
Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)
Solubility: 13.25 mg/mL (64.84 mM); Suspended solution; Need ultrasonic
-
4.
Add each solvent one by one: 10% EtOH >> 90% corn oil
Solubility: ≥ 13.25 mg/mL (64.84 mM); Clear solution
-
5.
-
6.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.23 mM); Clear solution
-
7.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (12.23 mM); Clear solution
Synonyms
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