[CAS NO. 871258-12-7] DLinDMA
PRODUCTS SPECIFICATIONS [871258-12-7]
DESCRIPTION [871258-12-7]
Overview
| MDL | MFCD31715447 |
|---|---|
| Molecular Weight | 616.06 |
| Molecular Formula | C41H77NO2 |
| SMILES | CCCCC/C=C\C/C=C\CCCCCCCCOCC(OCCCCCCCC/C=C\C/C=C\CCCCC)CN(C)C |
1 Publications Citing Use of MCE
Summary
DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery [1] .
In Vitro
The structure of DLinDMA can be divided into three main regions: the hydrocarbon chains, the linker and the headgroup [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
DLinDMA has virtually indistinguishable blood pharmacokinetic profiles in mice [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 162.32 mM ; Need ultrasonic)
Ethanol : ≥ 100 mg/mL ( 162.32 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6232 mL | 8.1161 mL | 16.2322 mL |
| 5 mM | 0.3246 mL | 1.6232 mL | 3.2464 mL |
| 10 mM | 0.1623 mL | 0.8116 mL | 1.6232 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.06 mM); Clear solution
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3.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.06 mM); Clear solution
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4.
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5.
Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (4.06 mM); Suspended solution; Need ultrasonic
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6.
Add each solvent one by one: 10% EtOH >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.06 mM); Clear solution