[CAS NO. 872044-70-7] AN0128

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PRODUCTS SPECIFICATIONS [872044-70-7]

Catalog

HY-10979

Brand

MCE

CAS

872044-70-7

DESCRIPTION [872044-70-7]

Overview

MDL	-
Molecular Weight	400.06
Molecular Formula	C20H16BCl2NO3
SMILES	OC1=CC=CN=C1C(OB(C2=CC(Cl)=C(C)C=C2)C3=CC(Cl)=C(C)C=C3)=O

For research use only. We do not sell to patients.

Summary

AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus , S. epidermidis , P. acnes , B. subtilis with minimum inhibitory concentration ( MIC ) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases ^[1] ^[2] .

In Vitro

AN0128 (compound 2g; 10 μM; 24-48 hours) shows strong inhibition of the release of pro-inflammatory cytokines (TNF-α, IL-1β) but no inhibition of IFN-γ or IL-4 release in human peripheral blood mononuclear cells (PBMCs) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AN0128 (1%, 5%; daily topical daub for 7 days) significantly reduces the formation of an inflammatory infiltrate and reduces bone loss ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each) ^[2]
Dosage:	1% AN0128 in 40% Transcutol P, 40% PBS, and 20% ethanol vehicle
Administration:	Daily topical daub for 7 days
Result:	Similar to Ketorolac, resulting 50% and 35% increase in bone area and bone volume respectively, and 38%, 42% decrease in bone loss and inflammation respectively.

Animal Model:	Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each) ^[2]
Dosage:	5% with Total toothpaste
Administration:	Applied daily via a cotton-tip applicator. for 7 days
Result:	Had more effect than Total toothpaste, resulting in a 33% increase in bone volume, and a 47% decrease in bone loss.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 312.45 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4996 mL	12.4981 mL	24.9963 mL
5 mM	0.4999 mL	2.4996 mL	4.9993 mL
10 mM	0.2500 mL	1.2498 mL	2.4996 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.20 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.20 mM); Clear solution

* All of the co-solvents are available by MCE.