[CAS NO. 877969-69-2] VPC-80051racemate

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PRODUCTS SPECIFICATIONS [877969-69-2]

Catalog

HY-126076

Brand

MCE

CAS

877969-69-2

DESCRIPTION [877969-69-2]

Overview

MDL	-
Molecular Weight	301.29
Molecular Formula	C16H13F2N3O
SMILES	O=C(C1=NNC2=C1C=CC=C2)NC(C3=CC=C(F)C(F)=C3)C

For research use only. We do not sell to patients.

Summary

VPC-80051 racemate is a racemate of VPC-80051. VPC-80051 is a prototype inhibitor of the hnRNP A1 splicing factor ^[1] .

In Vitro

VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. hnRNP A1 is a multifunctional RNA-binding protein that regulates alternative pre-mRNA splicing, transcription, nucleocytoplasmic shuttling, miRNA processing, and telomere elongation maintenance, as well as translation of cellular transcripts both in physiological and pathological conditions ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 331.91 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3191 mL	16.5953 mL	33.1906 mL
5 mM	0.6638 mL	3.3191 mL	6.6381 mL
10 mM	0.3319 mL	1.6595 mL	3.3191 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (8.30 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.30 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Carabet LA, et al. Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer. Molecules. 2019;24(4):763. Published 2019 Feb 20.