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[CAS NO. 882366-16-7] SBI-115
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-111534 |
| Brand: | MCE |
| CAS: | 882366-16-7 |
Overview
| MDL | MFCD07537427 |
|---|---|
| Molecular Weight | 340.78 |
| Molecular Formula | C14H13ClN2O4S |
| SMILES | O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)OC2=CC=CC(C)=C2 |
9 Publications Citing Use of MCE
- [1]Nat Commun. 2022 Oct 14;13(1):6081.
- [2]NPJ Biofilms Microbiomes. 2023 Feb 8;9(1):8.
- [3]Acta Pharm Sin B. 21 July 2021.
- [4]Pharmacol Res. 2022 Sep 21;106459.
- [5]Nutrients. 2023, 15(2), 255.
- [6]iScience. 2021, 102508.
- [7]Aquacult Rep. February 2022, 100997.
- [8]Discov Oncol. 2022 Jun 11;13(1):46.
- [9]STAR Protoc. 17 December 2021, 100938.
Summary
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5 [1] .
In Vitro
SBI-115 (100-200 µM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | shRNA-transfected ADPKD cholangiocytes |
| Concentration: | 100, 200 µM |
| Incubation Time: | 24 hours |
| Result: | Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 150 mg/mL ( 440.17 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9344 mL | 14.6722 mL | 29.3444 mL |
| 5 mM | 0.5869 mL | 2.9344 mL | 5.8689 mL |
| 10 mM | 0.2934 mL | 1.4672 mL | 2.9344 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution
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