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[CAS NO. 890405-51-3] 3BDO
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-U00434 |
| Brand: | MCE |
| CAS: | 890405-51-3 |
Overview
| MDL | MFCD30187363 |
|---|---|
| Molecular Weight | 327.33 |
| Molecular Formula | C18H17NO5 |
| SMILES | O=C1OC(COC2=C([N+]([O-])=O)C=CC=C2)CC1CC3=CC=CC=C3 |
8 Publications Citing Use of MCE
- [1]Appl Mater Today. 2021, 101066.
- [2]Acta Biomater. 2018 Nov;81:278-292.
- [3]EBioMedicine. 2023 Jan 27;88:104444.
- [4]Biochem Pharmacol. 2020 Aug;178:114038.
- [5]Aging. 2021 Mar 10;13(7):9542-9565.
- [6]Front Pharmacol. 2020 Nov 11;11:580407.
- [7]Int J Mol Med. 2020 Nov;46(5):1816-1826.
- [8]Neurochem Res. 2022 Oct 15.
IC50 & Target
|
mTOR
|
In Vitro
Phosphorylation of RPS6KB1 and EIF4EBP1 is significantly increased by 3BDO with vector alone but suppressed with FKBP1A overexpression. Rapamycin fails to decrease the phosphorylation of MTOR and RPS6KB1 in the presence of 3BDO. 3BDO suppresses the increase in MAP1LC3B puncta induced with rapamycin. 3BDO also inhibits the effect of rapamycin in HUVECs. The phosphorylation of Ser residues is decreased in HUVECs treated with 10 μM rapamycin, and 60 μM 3BDO reverses the phosphorylation. The results show that 3BDO suppresses the increased MAP1LC3B puncta number, MAP1LC3B-II level and decreased SQSTM1 protein level induced by rapamycin. 3BDO could dose- and time-dependently decrease FLJ11812 level in HUVECs. Overexpression of FLJ11812 reverses the inhibition of autophagy induced by 3BDO [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Immunofluorescence assay reveals that 3BDO treatment increases the level of p-p70S6K and decreases the protein level of ATG13 in plaque endothelium of mice. 3BDO does not affect the phosphorylation of mTOR direct downstream targets p70S6K and 4EBP1. As compare with controls, apoE -/- mice show inhibited endothelium autophagy and apoptosis with 3BDO treatment, so 3BDO protects against endothelium injury in atherosclerosis. 3BDO treatment stabilizes established atherosclerotic lesions in apoE -/- mice. In apoE -/- mice, as compare with controls, with 3BDO treatment, the serum level of IL-6 and IL-8 is significantly decreased [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid-liquid mixture
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 305.50 mM )
Ethanol : 20 mg/mL ( 61.10 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0550 mL | 15.2751 mL | 30.5502 mL |
| 5 mM | 0.6110 mL | 3.0550 mL | 6.1100 mL |
| 10 mM | 0.3055 mL | 1.5275 mL | 3.0550 mL |
References
- [1] Ge D, et al. Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy. 2014 Jun;10(6):957-71.
- [2] Peng N, et al. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E / mice. Sci Rep. 2014 Jul 1;4:5519.
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