[CAS NO. 892415-28-0] EAAT2activator1

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PRODUCTS SPECIFICATIONS [892415-28-0]

Catalog

HY-139692

Brand

MCE

CAS

892415-28-0

DESCRIPTION [892415-28-0]

Overview

MDL	-
Molecular Weight	331.80
Molecular Formula	C16H11ClFN3S
SMILES	FC1=CC=CC(Cl)=C1CSC2=CC=C(C3=NC=CC=C3)N=N2

For research use only. We do not sell to patients.

Summary

EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 ( EAAT2 ). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently ^[1] .

IC50 & Target

EAAT2 ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 75.35 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0139 mL	15.0693 mL	30.1386 mL
5 mM	0.6028 mL	3.0139 mL	6.0277 mL
10 mM	0.3014 mL	1.5069 mL	3.0139 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 1.67 mg/mL (5.03 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Xing X, et al. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011;21(19):5774-5777.