[CAS NO. 895460-70-5] BRD7586
PRODUCTS SPECIFICATIONS [895460-70-5]
DESCRIPTION [895460-70-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 407.89 |
| Molecular Formula | C17H14ClN3O3S2 |
| SMILES | O=C(CCS(=O)(C1=CC=C(C=C1)Cl)=O)NC2=NC(C3=CC=NC=C3)=CS2 |
Summary
BRD7586 is a cell-permeable small-molecule inhibitor of SpCas9 . BRD7586 is the smallest known anti-CRISPR [1] .
In Vitro
BRD7586 specifically engages SpCas9 but not Cas12a in cells
[1]
.
BRD7586 (0-20 μM; 24 h) dose-dependently inhibits SpCas9 in the HiBiT-knock-in assay in HEK293T cells
[1]
.
BRD7586 (20 μM; 48 h) enhances the ratio of on-target versus off-target in HEK293T cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.