[CAS NO. 9001-05-2] Catalase,Aspergillusniger
PRODUCTS SPECIFICATIONS [9001-05-2]
DESCRIPTION [9001-05-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | - |
| Molecular Formula | Unspecified |
| SMILES | [Catalase] |
Summary
Catalase is a key enzyme in the metabolism of H 2 O 2 and reactive oxygen species ( ROS ), and its expression and localization is markedly altered in tumors [1] . Free oxygen radical scavenger.
In Vitro
Catalase, the enzyme that metabolizes H 2 O 2 but also reacts with a multitude of other substrates. The active site of catalase contains an iron atom. Human catalase contains four identical subunits, each subunit containing four distinct domains and one prosthetic heme group. The four domains include: (1) a N-terminal arm which contains a distal histidine, an essential amino acid for the catalase reaction; (2) a β-barrel domain that contains eight β-barrels arranged in an antiparallel fashion with six α-helical insertions, conferring the hydrophobic core of the protein necessary for the tri-dimensional structure of the enzyme; (3) a connection domain which contains the tyrosine residue that binds the heme group; and finally (4) an α-helical domains, which is important for NADPH binding [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT03621995 | Assiut University |
Oxidative Stress
|
September 10, 2018 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 33.33 mg/mL (Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic
Synonyms