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[CAS NO. 900305-37-5] PFI-4
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-18664 |
| Brand: | MCE |
| CAS: | 900305-37-5 |
Overview
| MDL | MFCD14744412 |
|---|---|
| Molecular Weight | 380.44 |
| Molecular Formula | C21H24N4O3 |
| SMILES | O=C(NC1=C(N2CCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC |
Summary
IC50 & Target
IC50: 3.517 μM (BRPF2), >10 μM (BRD4 (1)), 0.172 μM (BRPF1B), >10 μM (TRIM24) [1] .
In Vitro
PFI-4 (1.25 µM; 7 or 11 days) inhibits differentiation of human osteoclasts [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Osteoclasts |
| Concentration: | 1.25 µM |
| Incubation Time: | 7 or 11 days |
| Result: | Significantly reduces MMP9 secretion in osteoclasts. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 26 mg/mL ( 68.34 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6285 mL | 13.1427 mL | 26.2854 mL |
| 5 mM | 0.5257 mL | 2.6285 mL | 5.2571 mL |
| 10 mM | 0.2629 mL | 1.3143 mL | 2.6285 mL |
References
- [1] Meier JC, et al. Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630.
- [2] Demont EH, et al. 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. (2014) ACS Med Chem Lett. 5(11):1190-1195.
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