[CAS NO. 900874-91-1] T-00127_HEV1
PRODUCTS SPECIFICATIONS [900874-91-1]
DESCRIPTION [900874-91-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 411.50 |
| Molecular Formula | C22H29N5O3 |
| SMILES | CC1=NC2=C(C3=CC=C(OC)C(OC)=C3)C(C)=NN2C(NCCN4CCOCC4)=C1 |
1 Publications Citing Use of MCE
Summary
T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta ( PI4KB ) inhibitor with an IC 50 of 60 nM.
IC50 & Target
|
PI4KB 60 nM (IC 50 ) |
In Vitro
T-00127_HEV1 shows more potent anti-poliovirus (PV) activity (EC 50 of 0.77 μM) than other candidate compounds (EC 50 of 1.7 to 4.7 μM). GW5074 and T-00127_HEV1 almost completely inhibit PI4KB kinase activity at 10 μM (3% and 5% of residual activity, respectively), in contrast to AN-12-H5 (108% of activity [no inhibition]) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 121.51 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4301 mL | 12.1507 mL | 24.3013 mL |
| 5 mM | 0.4860 mL | 2.4301 mL | 4.8603 mL |
| 10 mM | 0.2430 mL | 1.2151 mL | 2.4301 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.08 mM); Clear solution