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[CAS NO. 903895-98-7] FPRAgonist43
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19574 |
| Brand: | MCE |
| CAS: | 903895-98-7 |
Overview
| MDL | MFCD30182236 |
|---|---|
| Molecular Weight | 384.86 |
| Molecular Formula | C20H21ClN4O2 |
| SMILES | O=C(NC1=C(C(C)C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(Cl)C=C3 |
2 Publications Citing Use of MCE
Summary
FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist [1] [2] .
IC50 & Target
FPR1, FPR2/ALX [1]
In Vitro
FPR Agonist 43 (10
-5
-10
7
nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells
[1]
.
FPR Agonist 43 is also active in the GTPγ binding assay (IC
50
=207±51 nM)
[1]
.
FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors |
| Concentration: | 10 -5 , 10 -3 , 0.1, 10, 1000, 10 5 , 10 7 nM |
| Incubation Time: | |
| Result: | Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC 50 =11.6±1.9 nM). |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 37.5 mg/mL ( 97.44 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5983 mL | 12.9917 mL | 25.9835 mL |
| 5 mM | 0.5197 mL | 2.5983 mL | 5.1967 mL |
| 10 mM | 0.2598 mL | 1.2992 mL | 2.5983 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.40 mM); Clear solution
References
- [1] Planagumà A, et al. Lack of activity of 15-epi-lipoxin A₄ on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function. Clin Exp Immunol. 2013 Aug;173(2):298-309.
- [2] Forsman H, et al. What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? Scand J Immunol. 2011 Sep;74(3):227-234.
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