[CAS NO. 906439-72-3] COH34
PRODUCTS SPECIFICATIONS [906439-72-3]
DESCRIPTION [906439-72-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 293.38 |
| Molecular Formula | C18H15NOS |
| SMILES | CC1=CC=C(S/N=C/C2=C3C=CC=CC3=CC=C2O)C=C1 |
1 Publications Citing Use of MCE
Summary
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors [1] .
IC50 & Target
IC50: 0.37 nM (PARG) [1]
In Vitro
COH34 efficiently kills PARP inhibitor-resistant cancer cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years |
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 16.67 mg/mL ( 56.82 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4085 mL | 17.0427 mL | 34.0855 mL |
| 5 mM | 0.6817 mL | 3.4085 mL | 6.8171 mL |
| 10 mM | 0.3409 mL | 1.7043 mL | 3.4085 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1.67 mg/mL (5.69 mM); Clear solution