[CAS NO. 906669-07-6] KPLH1130

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PRODUCTS SPECIFICATIONS [906669-07-6]

Catalog

HY-128578

Brand

MCE

CAS

906669-07-6

DESCRIPTION [906669-07-6]

Overview

MDL	-
Molecular Weight	283.28
Molecular Formula	C15H13N3O3
SMILES	OC1=CC=C(C2=NNC(N2C3=CC=C(C)C=C3)=O)C(O)=C1

For research use only. We do not sell to patients.

Summary

KPLH1130 is a specific pyruvate dehydrogenase kinase ( PDK ) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice ^[1] .

IC50 & Target

PDK ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 135 mg/mL ( 476.56 mM ; Need ultrasonic)

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Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5301 mL	17.6504 mL	35.3008 mL
5 mM	0.7060 mL	3.5301 mL	7.0602 mL
10 mM	0.3530 mL	1.7650 mL	3.5301 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.25 mg/mL (7.94 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Min BK, et al. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype. Front Immunol. 2019 May 7;10:944.