[CAS NO. 90902-21-9] Broussonin E
PRODUCTS SPECIFICATIONS [90902-21-9]
DESCRIPTION [90902-21-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 288.34 |
| Molecular Formula | C17H20O4 |
| SMILES | OC1=CC(OC)=CC=C1CCCC2=CC=C(OC)C(O)=C2 |
Summary
Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis [1] .
IC50 & Target
|
ERK |
p38 MAPK |
JAK2 |
STAT3 |
IL-1β |
IL-6 |
COX-2 |
IL-10 |
In Vitro
Broussonin E (20 μM, 3 h) inhibits the LPS (
Lipopolysaccharides
, HY-D1056)-stimulated phosphorylation of ERK and p38 MAPK
[1]
.
Broussonin E can activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3
[1]
.
Broussonin E (0-20 μM, 3 h) can suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS
[1]
.
Broussonin E enhances the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | RAW264.7 cells |
| Concentration: | 2.5, 5, 10 and 20 |
| Incubation Time: | 3 h |
| Result: | Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.