[CAS NO. 910582-16-0] ZIKV-IN-2

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PRODUCTS SPECIFICATIONS [910582-16-0]

Catalog

HY-151445

Brand

MCE

CAS

910582-16-0

DESCRIPTION [910582-16-0]

Overview

MDL	-
Molecular Weight	574.75
Molecular Formula	C39H42O4
SMILES	[H][C@]12CCC([C@H]([C@@]1(CC[C@H]([C@]2(COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)C)O)C)/C=C/C6=CCOC6=O)=C

For research use only. We do not sell to patients.

Summary

ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC ₅₀ value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection . ZIKV-IN-2 can be used in research of Zika virus (ZIKV) ^[1] .

IC50 & Target

IC50: 38.86 μM (MTase) ^[1]

In Vitro

ZIKV-IN-2 (compound 3a; 0.08-50 μM) inhibits the expression of ZIKV E protein with an EC ₅₀ value of 6.17 μM and inhibits ZIKV replication and infection ^[1] .
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	Vero, Huh7 and A549 cells
Concentration:	0.08, 0.4, 2, 10, and 50 μM
Incubation Time:	96 hours
Result:	Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC ₅₀ >200 μM to all three cell lines.

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References

[1] Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710.