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[CAS NO. 910634-41-2] Litronesib
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-14846 |
| Brand: | MCE |
| CAS: | 910634-41-2 |
Overview
| MDL | MFCD19442197 |
|---|---|
| Molecular Weight | 511.70 |
| Molecular Formula | C23H37N5O4S2 |
| SMILES | CC(C)(C)C(N1[C@@](C2=CC=CC=C2)(CNS(CCNCC)(=O)=O)SC(NC(C(C)(C)C)=O)=N1)=O |
Summary
IC50 & Target
|
Eg5
|
In Vitro
Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) shows antitumor activity in a dose-dependently, and causes a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01059643 | Eli Lilly and Company |
Ovarian Cancer|Non Small Cell Lung Cancer|Prostate Cancer|Colorectal Cancer|Gastric Cancer|Esophageal Cancer|Cancer of Head and Neck
|
April 2011 | Phase 2 |
| NCT01214642 | Eli Lilly and Company |
Advanced Cancer
|
May 2008 | Phase 1 |
| NCT01358019 | Kyowa Kirin Co., Ltd. |
Solid Tumors
|
May 2011 | Phase 1 |
| NCT01214629 | Eli Lilly and Company |
Advanced Cancer|Metastatic Cancer
|
July 2007 | Phase 1 |
| NCT01025284 | Eli Lilly and Company |
Small Cell Lung Cancer
|
December 2009 | Phase 2 |
| NCT01214655 | Eli Lilly and Company |
Acute Leukemia
|
June 2008 | Phase 1 |
| NCT01416389 | Eli Lilly and Company |
Metastatic Breast Cancer
|
August 2011 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 97.71 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9543 mL | 9.7713 mL | 19.5427 mL |
| 5 mM | 0.3909 mL | 1.9543 mL | 3.9085 mL |
| 10 mM | 0.1954 mL | 0.9771 mL | 1.9543 mL |
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