[CAS NO. 91183-98-1]  UDP-GlcNAcdisodium

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PRODUCTS SPECIFICATIONS [91183-98-1]

Catalog
HY-112174
Brand
MCE
CAS
91183-98-1

DESCRIPTION [91183-98-1]

Overview

MDLMFCD00799985
Molecular Weight651.32
Molecular FormulaC17H25N3Na2O17P2
SMILESO[C@H]1[C@H](N2C(NC(C=C2)=O)=O)O[C@H](COP(OP(O[C@@H]3[C@@H]([C@H]([C@H](O)[C@@H](CO)O3)O)NC(C)=O)(O[Na])=O)(O[Na])=O)[C@H]1O

For research use only. We do not sell to patients.


Summary

UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).


In Vitro

OGT is a nucleocytoplasmic glycosyltransferase (uridine diphospho-N--acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase or O-GlcNAc transferase) assigned to the GT41 family in the CAZY (Carbohydrate-Active enZYme) database. Using UDP-GlcNAc Disodium Salt (UDP-GlcNAc) as the donor substrate, this enzyme modifies thousands of proteins by adding a unique N-acetylglucosamine residue onto acceptor substrates mainly confined within cytosol and nucleus [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.


Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 383.84 mM ; Need ultrasonic)

H 2 O : 125 mg/mL ( 191.92 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5353 mL 7.6767 mL 15.3534 mL
5 mM 0.3071 mL 1.5353 mL 3.0707 mL
10 mM 0.1535 mL 0.7677 mL 1.5353 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (3.19 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.19 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.19 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Uridine 5′-(trihydrogen diphosphate), P′-[2-(acetylamino)-2-deoxy-α-D-glucopyranosyl] ester, sodium salt (1:2)
Uridine 5′-(trihydrogen diphosphate), P′-[2-(acetylamino)-2-deoxy-α-D-glucopyranosyl] ester, disodium salt