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[CAS NO. 912288-64-3] YHO-13351freebase
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-12758A |
| Brand: | MCE |
| CAS: | 912288-64-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 483.62 |
| Molecular Formula | C26H33N3O4S |
| SMILES | N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(OC(CN(CC)CC)=O)CC3)S2 |
Summary
YHO-13351 free base is the prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 206.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0677 mL | 10.3387 mL | 20.6774 mL |
| 5 mM | 0.4135 mL | 2.0677 mL | 4.1355 mL |
| 10 mM | 0.2068 mL | 1.0339 mL | 2.0677 mL |
-
1.
References
- [1] Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63.
- [2] Shishido Y, et al. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013 Apr;33(4):1379-86.
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