[CAS NO. 915082-52-9] PDE4B-IN-2
PRODUCTS SPECIFICATIONS [915082-52-9]
DESCRIPTION [915082-52-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 387.88 |
| Molecular Formula | C19H18ClN3O2S |
| SMILES | O=C(O)CC1=CC=C(NC2=NC(C3=CC=C(Cl)S3)=NC(C)=C2CC)C=C1 |
Summary
PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC 50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC 50 =1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects [1] .
IC50 & Target
|
PDE4B 15 nM (IC 50 ) |
PDE4D 1.7 μM (IC 50 ) |
In Vitro
PDE4B-IN-2 (compound 33) does not inhibit CYP1A2, CYP3A4, CYP2C9, and CYP2D (IC
50
>10 µM)
[1]
.
PDE4B-IN-2 inhibits LPS-induced TNF-aproduction in vitro from mouseperipheral blood mononuclear cell (PBMC; IC
50
=0.5 M)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PDE4B-IN-2 (compound 33; 2 mg/kg; po) has a C
max
of 8.7 μg/mL and an AUC of 52.3 μg•h/mL in mice
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 64.45 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5781 mL | 12.8906 mL | 25.7812 mL |
| 5 mM | 0.5156 mL | 2.5781 mL | 5.1562 mL |
| 10 mM | 0.2578 mL | 1.2891 mL | 2.5781 mL |