[CAS NO. 91917-65-6] Ro15-4513

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PRODUCTS SPECIFICATIONS [91917-65-6]

Catalog

HY-103476

Brand

MCE

CAS

91917-65-6

DESCRIPTION [91917-65-6]

Overview

MDL	-
Molecular Weight	326.31
Molecular Formula	C15H14N6O3
SMILES	O=C(C1=C(CN2C)N(C=N1)C3=CC=C(N=[N+]=[N-])C=C3C2=O)OCC

For research use only. We do not sell to patients.

Summary

Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) ^[1] . Ro15-4513 is a potent ethanol antagonist ^[2] . Ro15-4513 has anti-anxiety effect ^[3] .

IC50 & Target

BZR ^[1] ; ethanol ^[2] ;

In Vitro

Ro15-4513 usually acts as a partial inverse agonist at GABA _A receptors, except an agonist for α4 and α6 subunit-containing ones ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing ^[2] .
Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABA _A receptor δ subunit-deficient mice ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/6J mice ^[2]
Dosage:	3 mg/kg
Administration:	I.p.; 10 min before being tested
Result:	Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03507569	Hoffmann-La Roche	Autism Spectrum Disorder	April 24, 2018	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Synonyms

4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester

Ethyl 8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Ro 15-4513