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[CAS NO. 924296-18-4] DUB-IN-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-50736 |
| Brand: | MCE |
| CAS: | 924296-18-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 337.33 |
| Molecular Formula | C20H11N5O |
| SMILES | N#CC1=C(C#N)N=C2C(/C(C3=C2C=CC=C3)=N/OCC4=CC=CC=C4)=N1 |
5 Publications Citing Use of MCE
Summary
DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs) , with an IC 50 of 0.85 μM for USP8 [1] .
IC50 & Target
IC50: 0.24 μM (USP8) [1]
In Vitro
DUBs-IN-1 (22 d) is an active inhibitor of ubiquitin-specific proteases, with an IC 50 of 0.85 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC 50 , >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC 50 s ranging from 0.5 μM to 1.5 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 296.45 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9645 mL | 14.8223 mL | 29.6446 mL |
| 5 mM | 0.5929 mL | 2.9645 mL | 5.9289 mL |
| 10 mM | 0.2964 mL | 1.4822 mL | 2.9645 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution
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