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[CAS NO. 92831-11-3] MN-64
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19351 |
| Brand: | MCE |
| CAS: | 92831-11-3 |
Overview
| MDL | MFCD00829158 |
|---|---|
| Molecular Weight | 264.32 |
| Molecular Formula | C18H16O2 |
| SMILES | O=C1C=C(C2=CC=C(C(C)C)C=C2)OC3=CC=CC=C13 |
3 Publications Citing Use of MCE
Summary
MN-64 is a potent tankyrase 1 inhibitor, with IC 50 s of 6 nM, 72 nM, 19.1 μM, and 39.4 μM for TNKS1 , TNKS2, ARTD1 and ARTD2, respectively.
IC50 & Target
|
TNKS1 6 nM (IC 50 ) |
TNKS2 72 nM (IC 50 ) |
ARTD1 19.1 μM (IC 50 ) |
ARTD2 39.4 μM (IC 50 ) |
In Vitro
MN-64 is a potent tankyrase 1 inhibitor, with IC 50 s of 6 nM, 72 nM, 19.1 μM, 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1 μM, and blocks STF luciferase activity at 200 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 378.33 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7833 mL | 18.9165 mL | 37.8329 mL |
| 5 mM | 0.7567 mL | 3.7833 mL | 7.5666 mL |
| 10 mM | 0.3783 mL | 1.8916 mL | 3.7833 mL |
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