[CAS NO. 93-07-2] Veratric acid
PRODUCTS SPECIFICATIONS [93-07-2]
DESCRIPTION [93-07-2]
Overview
| MDL | MFCD00002500 |
|---|---|
| Molecular Weight | 182.17 |
| Molecular Formula | C9H10O4 |
| SMILES | O=C(O)C1=CC=C(OC)C(OC)=C1 |
Summary
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant [1] and anti-inflammatory activities [3] . Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling [2] . Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation [3] .
IC50 & Target
COX-2 [3]
In Vitro
Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation and HDAC3 expression in RAW264.7 cells
[1]
.
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis
[3]
.
Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Veratric acid (40 mg/kg, p.o., b.w.) significantly promotes ventricular function, reduces lipid peroxidation and increases antioxidants in l-NAME-induced hypertensive rats [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 110 mg/mL ( 603.83 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.4894 mL | 27.4469 mL | 54.8938 mL |
| 5 mM | 1.0979 mL | 5.4894 mL | 10.9788 mL |
| 10 mM | 0.5489 mL | 2.7447 mL | 5.4894 mL |
References
- [1] Choi WS, et al. Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. Int J Mol Med. 2015 Jan;35(1):202-10.
- [2] Saravanakumar M, et al. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. Br J Nutr. 2015 Nov 14;114(9):1385-94.
- [3] Shin SW, et al. Antagonist effects of veratric acid against UVB-induced cell damages. Molecules. 2013 May 10;18(5):5405-19.
Synonyms