[CAS NO. 936095-50-0] UBP316
PRODUCTS SPECIFICATIONS [936095-50-0]
DESCRIPTION [936095-50-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 429.45 |
| Molecular Formula | C20H19N3O6S |
| SMILES | OC(C(SC(C1=CC=CC=C1)=C2)=C2CN3C(N(C=C(C)C3=O)C[C@H](N)C(O)=O)=O)=O |
Summary
UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a K b value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist [1] .
IC50 & Target
Kb: 1.4 nM (GluK1) [1]
In Vitro
UBP316 is ineffective at GluK2 (GluR6) receptors at all concentrations tested (up to 100 μM) and had no effect at GluK3 (GluR7) when tested at 1 μM
[1]
.
UBP316 (200 nM) reduces short-term facilitation of pre-synaptic calcium transients following repetitive spikes
[1]
.
UBP316 effectively antagonises GluK1-mediated depression of excitatory transmission in CA1 region of the hippocampus in vitro
[1]
.
UBP316 blocks induction of NMDA receptor-independent long-term potentiation (LTP)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
1M NaOH : 80 mg/mL ( 186.28 mM ; ultrasonic and adjust pH to 11 with NaOH)
DMSO : 2 mg/mL ( 4.66 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3286 mL | 11.6428 mL | 23.2856 mL |
| 5 mM | 0.4657 mL | 2.3286 mL | 4.6571 mL |
| 10 mM | 0.2329 mL | 1.1643 mL | 2.3286 mL |