[CAS NO. 94-25-7] Butamben
PRODUCTS SPECIFICATIONS [94-25-7]
DESCRIPTION [94-25-7]
Overview
| MDL | MFCD00017112 |
|---|---|
| Molecular Weight | 193.24 |
| Molecular Formula | C11H15NO2 |
| SMILES | O=C(OCCCC)C1=CC=C(N)C=C1 |
Summary
In Vitro
Butamben (500 μM) blocks 90% of the control barium current, and this level is reached within 4 min in PC12 cells
[2]
.
Butamben (100 μM; 2-10 min) increases the inactivation of the fast Na
+
channels, but not of the slow Na
+
channels
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Butamben (0.5-50 mM; the distal portion of the tail was immersed for 2 min) has an S-shape dose-dependent analgesic activity in the radiant heat tail-flick assay of mice [4] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 517.49 mM )
H 2 O : 0.1 mg/mL ( 0.52 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.1749 mL | 25.8746 mL | 51.7491 mL |
| 5 mM | 1.0350 mL | 5.1749 mL | 10.3498 mL |
| 10 mM | 0.5175 mL | 2.5875 mL | 5.1749 mL |
References
- [1] Cereda CM, et al. Liposomal butamben gel formulations: toxicity assays and topical anesthesia in an animal model. J Liposome Res. 2017 Mar;27(1):74-82.
- [2] Rampaart LJA, et, al. The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells. Anesth Analg. 2008 Jun;106(6):1778-83.
- [3] Berg RJV, et, al. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. Anesthesiology. 1995 Jun;82(6):1463-73.
- [4] Kolesnikov YA, et, al. Analgesic synergy between topical morphine and butamben in mice. Anesth Analg. 2003 Oct;97(4):1103-7, table of contents.
Synonyms