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[CAS NO. 940310-85-0] NVP-BHG712
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-13258A |
| Brand: | MCE |
| CAS: | 940310-85-0 |
Overview
| MDL | MFCD20272929 |
|---|---|
| Molecular Weight | 503.48 |
| Molecular Formula | C26H20F3N7O |
| SMILES | CC1=CC=C(C=C1NC2=NC(C3=CC=CN=C3)=NC4=C2C=NN4C)C(NC5=CC=CC(C(F)(F)F)=C5)=O |
3 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 3.3 nM (EphA2), 3 nM (EphB4) [2] .
In Vitro
NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity. The data suggests a close cross talk between the VEGFR and EphR signaling during vessel formation [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
NVP-BHG712 (3, 10 and 30 mg/kg, p.o., daily) inhibits VEGF driven tissue growth and angiogenesis [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Mice arrying chambers [1] . |
| Dosage: | 3, 10 and 30 mg/kg. |
| Administration: | P.O. daily for 4 days. |
| Result: | Significantly inhibited VEGF stimulated tissue formation and vascularization at doses of daily 3 mg/kg. Administration of 10 mg/kg/kg p.o. was sufficient to reverse VEGF enhanced tissue formation and vessel growth. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 31.25 mg/mL ( 62.07 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9862 mL | 9.9309 mL | 19.8618 mL |
| 5 mM | 0.3972 mL | 1.9862 mL | 3.9724 mL |
| 10 mM | 0.1986 mL | 0.9931 mL | 1.9862 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.13 mM); Clear solution
References
- [1] Tröster A, et al. NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem. 2018 Aug 20;13(16):1629-1633.
- [2] Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.
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