[CAS NO. 941521-45-5] BAZ1A-IN-1
PRODUCTS SPECIFICATIONS [941521-45-5]
DESCRIPTION [941521-45-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 340.36 |
| Molecular Formula | C16H12N4O3S |
| SMILES | O=C(NC1=CC=CC([N+]([O-])=O)=C1)NC2=NC(C3=CC=CC=C3)=CS2 |
Summary
BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a K D value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A , but weak or no activity against cancer cells with a low expression level of BAZ1A [1] .
IC50 & Target
BAZ1A [1]
In Vitro
BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC 50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells |
| Concentration: | 0.015-100 μM |
| Incubation Time: | 96 hours |
| Result: | Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 73.45 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9381 mL | 14.6903 mL | 29.3807 mL |
| 5 mM | 0.5876 mL | 2.9381 mL | 5.8761 mL |
| 10 mM | 0.2938 mL | 1.4690 mL | 2.9381 mL |