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[CAS NO. 943962-47-8] BMS-303141
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-16107 |
| Brand: | MCE |
| CAS: | 943962-47-8 |
Overview
| MDL | MFCD25976797 |
|---|---|
| Molecular Weight | 424.30 |
| Molecular Formula | C19H15Cl2NO4S |
| SMILES | O=S(C1=CC(Cl)=CC(Cl)=C1O)(NC2=CC(C3=CC=CC=C3)=CC=C2OC)=O |
8 Publications Citing Use of MCE
- [1]Mol Cell. 2022 Aug 9;S1097-2765(22)00647-5.
- [2]J Pathol. 2020 Dec;252(4):358-370.
- [3]J Bone Miner Res. 2021 Jun 22.
- [4]FASEB J. 2022 Jul;36(7):e22418.
- [5]Int J Mol Sci. 2022 Sep 15;23(18):10747.
- [6]Int J Mol Sci. 2022, 23(18), 10747.
- [7]J Agric Food Chem. 2021 Jul 29.
- [8]Chem Biol Interact. 2022 Sep 26;367:110199.
Summary
BMS-303141 is a potent, cell-permeable ATP-citrate lyase ( ACL ) inhibitor with an IC 50 of 0.13 μM.
IC50 & Target
IC50: 0.13 uM (ACL) [1]
In Vitro
In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC 50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Chronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 25 mg/mL ( 58.92 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3568 mL | 11.7841 mL | 23.5682 mL |
| 5 mM | 0.4714 mL | 2.3568 mL | 4.7136 mL |
| 10 mM | 0.2357 mL | 1.1784 mL | 2.3568 mL |
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