[CAS NO. 944328-88-5] QS11

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PRODUCTS SPECIFICATIONS [944328-88-5]

Catalog

HY-12762

Brand

MCE

CAS

944328-88-5

DESCRIPTION [944328-88-5]

Overview

MDL	MFCD18086864
Molecular Weight	567.68
Molecular Formula	C36H33N5O2
SMILES	OC[C@H](CC1=CC=CC=C1)NC2=C3C(N(CC4=CC=C(C5=CC=CC=C5)C=C4)C=N3)=NC(OC6=CC=C(CCC7)C7=C6)=N2

For research use only. We do not sell to patients.

Summary

QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC ₅₀ of 1.5 µM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells ^[1] .

IC50 & Target

EC50: 1.5 µM (ARFGAP1) ^[1]

In Vitro

QS11 binds and inhibits the GTPase activating protein of ARFGAP1, suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking ^[1] .
QS11 (2.5 μM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a conditioned medium, whereas Wnt-3a treatment alone increases reporter activity 40-fold ^[2] .
QS11 shows potent activity (EC ₅₀ =0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells ^[2] .
QS11 effectively reduces in vitro migration of metastatic human breast cancer cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 176.16 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7616 mL	8.8078 mL	17.6156 mL
5 mM	0.3523 mL	1.7616 mL	3.5231 mL
10 mM	0.1762 mL	0.8808 mL	1.7616 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

* All of the co-solvents are available by MCE.