[CAS NO. 947669-86-5] WWL113

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Catalog:	HY-110148
Brand:	MCE
CAS:	947669-86-5

Overview

MDL	-
Molecular Weight	466.53
Molecular Formula	C29H26N2O4
SMILES	CN(CC1=CC(C2=CC=NC=C2)=CC=C1)C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O

For research use only. We do not sell to patients.

Summary

WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC ₅₀ values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases) ^[1] .

IC50 & Target

IC50: 120 nM (Ces3), 100 nM (Ces1f) ^[1] .

In Vitro

Ces3 and Ces1f are endoplasmic reticulum glycoproteins that have been previously associated with adipocyte lipolysis. WWL113 inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM ^[1] .
WWL113 (1 μM) significantly increases UCP1 protein expression in brown adipocytes ^[2] .
WWL113 has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2 ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WWL113 (30 mg/kg, orally once a day) results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance ^[1] .
WWL113 ameliorates obesity-diabetes in mice ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old db/db mice (n = 10 per group) ^[1] .
Dosage:	30 mg/kg.
Administration:	Orally once a day for 3 weeks.
Result:	Corrected multiple features of metabolic syndrome in db/db mice.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20.83 mg/mL ( 44.65 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1435 mL	10.7174 mL	21.4348 mL
5 mM	0.4287 mL	2.1435 mL	4.2870 mL
10 mM	0.2143 mL	1.0717 mL	2.1435 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.46 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Dominguez, E., Galmozzi, A., Chang, J.W., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat. Chem. Biol. 10(2), 113-121 (2014).
[2] Galmozzi, et al. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11;9(5):1584-1593.
[3] Turcotte C, et al. The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors. J Immunol. 2017 Apr 15;198(8):3255-3263.

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