- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Inhibitors
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 947699-46-9] ZIKV-IN-3
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-151446 |
| Brand: | MCE |
| CAS: | 947699-46-9 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 587.75 |
| Molecular Formula | C39H41NO4 |
| SMILES | O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@@](COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)(C)/C(CC[C@@]23C)=N/O)=C |
Summary
IC50 & Target
IC50: 18.34 μM (MTase) [1]
In Vitro
ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC
50
value of 0.76 μM and has anti-ZIKV effect with EC
50
values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively
[1]
.
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC
50
value of 0.38 μM and inhibits ZIKV replication and infection
[1]
.
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells
[1]
.
Vero, Huh7 and A549 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Vero, Huh7 and A549 cells |
| Concentration: | 0.08, 0.4, 2, 10, and 50 μM |
| Incubation Time: | 96 hours |
| Result: | Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC 50 >200 μM to all three cell lines. |
Western Blot Analysis [1]
| Cell Line: | Vero cells |
| Concentration: | 0.08, 0.4, 2, 10, and 50 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the expression of ZIKV E protein in a dose-dependent manner. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.