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[CAS NO. 948557-43-5] Tie2 kinase inhibitor 1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-100556 |
| Brand: | MCE |
| CAS: | 948557-43-5 |
Overview
| MDL | MFCD18384977 |
|---|---|
| Molecular Weight | 439.53 |
| Molecular Formula | C26H21N3O2S |
| SMILES | O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2)C=C1)C |
1 Publications Citing Use of MCE
Summary
IC50 & Target
IC50: 250 nM (Tie2) [1]
In Vitro
Tie2 kinase inhibitor 1 (compound 5) has an IC
50
of 50 μM for p38 and has moderate to excellent cellular activities (cell IC
50
=232 nM)
[1]
.
Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2)
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Athymic nude mice (6- to 8-week-old females) [1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneally; twice a week for 6 weeks |
| Result: | Resulted in statistically significant reductions in tumor volume. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 17.86 mg/mL ( 40.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2752 mL | 11.3758 mL | 22.7516 mL |
| 5 mM | 0.4550 mL | 2.2752 mL | 4.5503 mL |
| 10 mM | 0.2275 mL | 1.1376 mL | 2.2752 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1.79 mg/mL (4.07 mM); Clear solution
References
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