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[CAS NO. 956025-83-5] 3MB-PP1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-102069 |
| Brand: | MCE |
| CAS: | 956025-83-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 295.38 |
| Molecular Formula | C17H21N5 |
| SMILES | NC1=C2C(N(C(C)(C)C)N=C2CC3=CC=CC(C)=C3)=NC=N1 |
Summary
3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 ( Plk1 ) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 ( Cdk8 ). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase ( Leu93-ZIPK ; IC 50 =2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division [1] [2] [3] .
IC50 & Target
|
Leu93-ZIPK 2 μM (IC 50 ) |
In Vitro
3MB-PP1 (5 μM; 3 hours) stimulates hyphal growth in a strain bearing analog-sensitive alleles of SSN3 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 338.55 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3855 mL | 16.9273 mL | 33.8547 mL |
| 5 mM | 0.6771 mL | 3.3855 mL | 6.7709 mL |
| 10 mM | 0.3385 mL | 1.6927 mL | 3.3855 mL |
References
- [1] Burkard ME, et al. Enabling and disabling polo-like kinase 1 inhibition through chemical genetics. ACS Chem Biol. 2012 Jun 15;7(6):978-81.
- [2] Hollomon JM, et al. The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway. PLoS Genet. 2022;18(1):e1009622. Published 2022 Jan 4.
- [3] Al-Ghabkari A, et al. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. 2018 Nov;86(11):1211-1217.
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