[CAS NO. 911-40-0] 7-keto-Deoxycholicacid
PRODUCTS SPECIFICATIONS [911-40-0]
DESCRIPTION [911-40-0]
Overview
| MDL | MFCD00271373 |
|---|---|
| Molecular Weight | 406.56 |
| Molecular Formula | C24H38O5 |
| SMILES | O[C@@H](C[C@@](C1)2[H])CC[C@]2(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@@H]([C@H](C)CCC(O)=O)CC[C@@]4([H])[C@]3([H])C1=O |
Summary
In Vitro
7-keto-lithocholic acid shows an increasing bioconversion rate with addition of an equimolar concentration of deoxycholic acid (which itself is not metabolized)
[1]
.
7-keto-lithocholic acid is induced by deoxycholic acid and then it's metabolized
[1]
.
E
.
lentum
-like c-25 converts 81.7% of 2 mM cholic acid to deoxycholic acid and 3.7% to 7-keto-deoxycholic acid under anaerobic incubation
[2]
.
E
.
lentum
-like c-25 converts 91.5% of 150 mg/mL cholic acid to deoxycholic acid and 1.1% to 7-keto-deoxycholic acid under anaerobic incubation
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
human
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 245.97 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4597 mL | 12.2983 mL | 24.5966 mL |
| 5 mM | 0.4919 mL | 2.4597 mL | 4.9193 mL |
| 10 mM | 0.2460 mL | 1.2298 mL | 2.4597 mL |
References
- [1] Sutherland JD, et al. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum. J Lipid Res. 1982 Jul;23(5):726-32.
- [2] Takahashi T, et al. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994 Nov;77(11):3275-86.
Synonyms