Antifungal agent 41
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 638.14 |
| Molecular Formula | C22H18Cl4N4Se2 |
| SMILES | ClC1=CC=C(C([Se][Se]C(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)CN4C=CN=C4)C(Cl)=C1 |
Summary
In Vitro
Antifungal agent 41 (0.25-128 μg/mL) shows antifungal activities to
C.alb
,
C.alb
(sc5314),
C.gla
,
C.par
,
C.kru
,
C.zey
,
C.neo
and
A.f
with MIC values of 2, 1, 8, 2, 8, 0.25, 4 and 1 μg/mL, respectively
[1]
.
Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against pathogenic fluconazole-resistant
Candida albicans
with MIC values of 2, 8, 4, 2 and 4 μg/mL for strain CaR, 17#, 632, 901 and 904, respectively
[1]
.
Antifungal agent 41 (0-64 μg/mL; 24 h) shows antifungal activities against
Candida albicans
with MFC value of 16, 8, 16, >64, 16, 2 and 4 μg/mL for
C.alb
,
C.alb
(sc5314), strain CaR, 17#, 632, 901 and 904, respectively
[1]
.
Antifungal agent 41 (0-1024 μg/mL; 1.5-24 h) inhibits
C.alb
ATCC SC5314 and CPCC400616 biofilms with SMIC
50
s of 0.5 μg/mL and 0.5-4 μg/mL, with SMIC
80
s of 4-32 μg/mL and 2-4 μg/mL, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay [1]
| Cell Line: | HL-60, MDA-MB-231 and PC-3 cell lines |
| Concentration: | 0-100 μM |
| Incubation Time: | 24 h |
| Result: | Inhibited growth of HL-60, MDA-MB-231 and PC-3 cells with IC 50 s of 32.53, 6.25 and 1.43 μM, respectively. |
In Vivo
Antifungal agent 4 (6-12 mg/kg; i.p. once daily for 5 days) shows in vivo antifungal effects [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Mice with C.alb ATCC SC5314 infection [1] |
| Dosage: | 6 mg/kg and 12 mg/kg |
| Administration: | Intraperitoneal injection; 6 mg/kg and 12mg/kg once daily; for 5 days |
| Result: | Significantly reduced the kidney fungal burden of C.alb . |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.