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[CAS NO. 68941-95-7] 5-Fluorouracil- 15 N 2
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-90006S2 |
| Brand: | MCE |
| CAS: | 68941-95-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 132.06 |
| Molecular Formula | C4H3F15N2O2 |
| SMILES | O=C1C(F)=C[15NH]C([15NH]1)=O |
Summary
5-Fluorouracil- 15 N 2 is the 15 N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs [1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
5-Fluorouracil- 15 N 2 Related Antibodies
- ALIX Antibody
- CNPase Antibody
- COX IV Antibody
- COX2 Antibody
- Cyclin B1 Antibody (YA486)
- Cyclin D1 Antibody (YA485)
- Cytochrome C Antibody
- E-Cadherin Antibody (YA778)
- E-Cadherin Antibody (YA470)
- Fatty Acid Synthase Antibody
- FosB Antibody
- GAPDH Antibody
- GFAP Antibody (YA755)
- GFAP Antibody (YA416)
- GFP Antibody
- FKBP52 Antibody
- Cleaved-PARP1 Antibody
- c-Myc Antibody
- Toll-Like Receptor 3 Antibody (YA659)
- Alkaline Phosphatase Antibody
- BrdU Antibody (YA578)
- COX2/Cyclooxygenase 2 Antibody
- Ctip2 Antibody
- Cyclin A2 Antibody
- DYKDDDDK Tag (FLAG) Antibody
- EEA1 Antibody
- EpCAM Antibody (YA772)
- FIP200 Antibody
- Lamin A/C Antibody
- Lamin B1 Antibody
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
- [2] Han R, et al. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and NSC 123127 for enhanced therapeutic efficacy. J Drug Target. 2016 Jun 29:1-28. [Epub ahead of print]
- [3] Zeng Q, et al. Knockdown of NFBD1/MDC1 enhances chemosensitivity to NSC 119875 or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells. Mol Cell Biochem. 2016 Jul;418(1-2):137-46.
- [4] Jones DH, et al. Ten-Year and Beyond Follow-up After Treatment With Highly Purified Liquid-Injectable Silicone for HIV-Associated Facial Lipoatrophy: A Report of 164 Patients. Dermatol Surg. 2019 Jul;45(7):941-948.
- [5] McQuade RM, et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil. 2016 Jun 28.
- [6] Yin L, et al. Antitumor effects of oncolytic herpes simplex virus type 2 against colorectal cancer in vitro and in vivo. Ther Clin Risk Manag. 2017 Feb 7;13:117-130.
- [7] Snyder SM, et al. Initial Experience with Topical Fluorouracil for Treatment of HIV-Associated Anal Intraepithelial Neoplasia. J Int Assoc Physicians AIDS Care (Chic). 2011;10(2):83-88.
- [8] Pek Yee Lum, et al. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell. 2004 Jan 9;116(1):121-37.
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