[CAS NO. 18472-51-0]  Chlorhexidine (digluconate)

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [18472-51-0]

Catalog
HY-B0608
Brand
MCE
CAS
18472-51-0

DESCRIPTION [18472-51-0]

Overview

MDL-
Molecular Weight897.76
Molecular FormulaC34H54Cl2N10O14
SMILESN=C(NC(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)=N)NC2=CC=C(Cl)C=C2.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO

For research use only. We do not sell to patients.


Summary

Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi . Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis [1] [2] [3] .


In Vitro

Chlorhexidine digluconate (0.00001%, 0.00005%, 0.0001%, 0.0005%; 1-4 h) demonstrates a cytotoxic effect on CHO cells. Chlorhexidine digluconate reduces the activity of dehydrogenase of CHO cells in a dose-dependent and a time-dependent manner [2] .
Chlorhexidine digluconate (0.00005%, 0.0001%, 0.0005%; 1 h) causes the amount of cell apoptosis of about 1.62%, 5.51%, and 5.47%, respectively. The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively [2] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay [2]

Cell Line: Chinese hamster ovary cells
Concentration: 0.00001%, 0.00005%, 0.0001%, 0.0005%
Incubation Time: 1, 2, 4 h
Result: Demonstrated a cytotoxic effect on CHO cells.

Apoptosis Analysis [2]

Cell Line: Chinese hamster ovary cells
Concentration: 0.00005%, 0.0001%, 0.0005%
Incubation Time: 1 h
Result: After a 1 hour treatment, the amount of cell apoptosis was about 1.62%, 5.51%, and 5.47%, respectively.
The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively.

In Vivo

Chlorhexidine gluconate (0.05%, 0.025%; One-time intraperitoneal injection) with 0.05% lavage has significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only [1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g) [1]
Dosage: Chlorhexidine gluconate 0.05% and 0.025%
Administration: One-time intraperitoneal injection
Result: With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.

Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT03859908 Universidad de El Salvador
Surgical Site Infection
April 5, 2019 Phase 4
NCT04485312 Cairo University
Disabilities Multiple
July 15, 2020 Not Applicable
NCT01411891 University of Wisconsin, Madison
Catheter Infections|Spinal Catheter (Epidural) (Subdural); Complications, Infection or Inflammation
August 2011 Phase 4

Appearance

Liquid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Solution, -20°C, 2 years


Solvent & Solubility

In Vitro:

H 2 O : 100 mg/mL ( 111.39 mM ; Need ultrasonic)

DMSO : ≥ 38 mg/mL ( 42.33 mM )

* "≥" means soluble, but saturation unknown.

In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (111.39 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MedChemExpress (MCE).