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Chemistry
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[CAS NO. 18472-51-0] Chlorhexidine (digluconate)

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Catalog:	HY-B0608
Brand:	MCE
CAS:	18472-51-0

Overview

MDL	-
Molecular Weight	897.76
Molecular Formula	C34H54Cl2N10O14
SMILES	N=C(NC(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)=N)NC2=CC=C(Cl)C=C2.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO.O[C@H]([C@@H](O)C(O)=O)[C@H](O)[C@H](O)CO

For research use only. We do not sell to patients.

6 Publications Citing Use of MCE

[1]Nat Commun. 2021 Mar 29;12(1):1940.
[2]Cell Death Dis. 2022 Apr 22;13(4):396.
[3]Mol Oncol. 2020 Feb;14(2):373-386.
[4]Front Cell Dev Biol. 30 March 2021.
[5]Cell Signal. 2021 Apr 3;110002.
[6]Genes (Basel). 2021, 12(4), 537.

Summary

Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi . Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis ^[1] ^[2] ^[3] .

In Vitro

Chlorhexidine digluconate (0.00001%, 0.00005%, 0.0001%, 0.0005%; 1-4 h) demonstrates a cytotoxic effect on CHO cells. Chlorhexidine digluconate reduces the activity of dehydrogenase of CHO cells in a dose-dependent and a time-dependent manner ^[2] .
Chlorhexidine digluconate (0.00005%, 0.0001%, 0.0005%; 1 h) causes the amount of cell apoptosis of about 1.62%, 5.51%, and 5.47%, respectively. The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively ^[2] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorhexidine (digluconate) Related Antibodies

ALIX Antibody
CNPase Antibody
COX IV Antibody
COX2 Antibody
Cyclin B1 Antibody (YA486)
Cyclin D1 Antibody (YA485)
Cytochrome C Antibody
E-Cadherin Antibody (YA778)
E-Cadherin Antibody (YA470)
Fatty Acid Synthase Antibody
FosB Antibody
GAPDH Antibody
GFAP Antibody (YA755)
GFAP Antibody (YA416)
GFP Antibody
FKBP52 Antibody
Cleaved-PARP1 Antibody
c-Myc Antibody
Toll-Like Receptor 3 Antibody (YA659)
COX2/Cyclooxygenase 2 Antibody
Ctip2 Antibody
Cyclin A2 Antibody
DYKDDDDK Tag (FLAG) Antibody
EEA1 Antibody
EpCAM Antibody (YA772)
FIP200 Antibody
Lamin A/C Antibody
Lamin B1 Antibody
p53 Antibody (YA250)
p53 (acetyl K382) Antibody

Cell Cytotoxicity Assay ^[2]

Cell Line:	Chinese hamster ovary cells
Concentration:	0.00001%, 0.00005%, 0.0001%, 0.0005%
Incubation Time:	1, 2, 4 h
Result:	Demonstrated a cytotoxic effect on CHO cells.

Apoptosis Analysis ^[2]

Cell Line:	Chinese hamster ovary cells
Concentration:	0.00005%, 0.0001%, 0.0005%
Incubation Time:	1 h
Result:	After a 1 hour treatment, the amount of cell apoptosis was about 1.62%, 5.51%, and 5.47%, respectively. The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively.

In Vivo

Chlorhexidine gluconate (0.05%, 0.025%; One-time intraperitoneal injection) with 0.05% lavage has significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only ^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g) ^[1]
Dosage:	Chlorhexidine gluconate 0.05% and 0.025%
Administration:	One-time intraperitoneal injection
Result:	With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03859908	Universidad de El Salvador	Surgical Site Infection	April 5, 2019	Phase 4
NCT04485312	Cairo University	Disabilities Multiple	July 15, 2020	Not Applicable
NCT01411891	University of Wisconsin, Madison	Catheter Infections\|Spinal Catheter (Epidural) (Subdural); Complications, Infection or Inflammation	August 2011	Phase 4
NCT02386592	Boston University\|University Teaching Hospital, Lusaka, Zambia\|Zambia Center for Applied Health Research and Development\|Children´s Hospital of Philadelphia	Neonatal Sepsis\|Neonatal Mortality	September 1, 2015	Not Applicable
NCT00719329	Johns Hopkins Bloomberg School of Public Health\|Dhaka Shishu Hospital\|Shimantik, Bangladesh\|Thrasher Research Fund	Infection	August 2008	Not Applicable
NCT03140254	CareFusion	Preoperative Skin Preparation	September 2016	Phase 2
NCT04794231	Istanbul Medeniyet University	Catheter-Related Infections	May 1, 2018	Not Applicable
NCT04438434	University of Milan\|BMG Pharma	Impacted Third Molar Tooth\|Healing Surgical Wounds	June 2020	Phase 3
NCT01740245	AGUNCO Obstetrics and Gynecology Centre	Antisepsis Regimen After Surgical Treatment of HPV Infected Lesions		Phase 4
NCT03139409	Cairo University	Recurrent Caries Incidence	July 20, 2017	Not Applicable
NCT00272675	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|Onze Lieve Vrouwe Gasthuis	Nosocomial Infection\|Respiratory Tract Infection\|Surgical Site Infection	August 2003	Phase 2\|Phase 3
NCT02756377	Islamic Azad University, Tehran	Periodontal Diseases	May 2014	Phase 2\|Phase 3
NCT03925155	Montefiore Medical Center	Cesarean Section Complications	May 1, 2020	Phase 3
NCT01286168	Mayo Clinic\|University of California, San Francisco\|Ethicon, Inc.	Nonmalignant Breast Conditions\|Breast Cancer	May 2011	Phase 2
NCT01906242	Federal University of Pelotas	Denture Hygiene Protocol	April 2013	Not Applicable
NCT05178823	Semmelweis University	Gingival Diseases\|Caries	June 1, 2017	Phase 4
NCT03295461	Postgraduate Institute of Dental Sciences Rohtak	Periodontitis	March 2013	Not Applicable
NCT02788786	Johns Hopkins Bloomberg School of Public Health\|Bill and Melinda Gates Foundation	Periodontitis\|Premature Birth of Newborn	June 27, 2016	Phase 2
NCT02215460	University of Taubate\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Periodontitis	April 2012	Phase 4
NCT02252588	University of Minnesota\|Veterans Medical Research Foundation\|Flight Attendant Medical Research Institute	Chronic Obstructive Pulmonary Disease	September 1, 2014	Phase 2
NCT05679661	Huang YuGuang\|Peking Union Medical College Hospital	Postoperative Complications	February 6, 2023	Not Applicable
NCT03919942	Federal University of the Valleys of Jequitinhonha and Mucuri	Pericoronitis	April 19, 2019	Not Applicable
NCT04376268	Yuzuncu Y?l University	Impacted Third Molar Tooth	January 15, 2019	Phase 4
NCT01040286	Dexcel Pharma Technologies Ltd.	Periodontitis	August 2009	Phase 2
NCT03801187	Università Vita-Salute San Raffaele	Peri-implantitis	July 2, 2018	Not Applicable
NCT03412734	TriHealth Inc.	Hysterectomy	May 18, 2018	Phase 4
NCT02294604	Taipei Medical University Shuang Ho Hospital	Hand Disinfection	April 2015	Not Applicable
NCT02526667	Medline Industries	Surgery	August 2015	Phase 3
NCT01079663	Dexcel Pharma Technologies Ltd.	Peri-implantitis	March 2010	Phase 2
NCT04845672	Marmara University	Skin Microbiota	February 15, 2021	Not Applicable
NCT06002295	Sheikh Zayed Federal Postgraduate Medical Institute	Neonatal Sepsis\|Omphalitis	September 12, 2020	Phase 2
NCT05741866	The University of Queensland\|Queensland Children´s Hospital\|Royal Brisbane and Women´s Hospital\|University Hospital of Poitiers\|Griffith University	Vascular Access Complication\|Device Related Infection\|Device Related Sepsis\|Device Site Reactions\|Catheter Infection\|Catheter Complications\|Catheter-Related Infections\|Catheter Related Complication\|Occlusive Dressings\|Wound Infection\|Wound of Skin\|Wound	May 3, 2023	Not Applicable
NCT03385304	University of Maryland, Baltimore\|McMaster University\|United States Department of Defense	Surgical Site Infection\|Unplanned Fracture-Related Reoperation\|Open Appendicular Fracture	April 8, 2018	Phase 4
NCT01122862	GlaxoSmithKline	Healthy Subjects	April 2010	Phase 2
NCT01090479	Northwestern University\|Sage Products, Inc.	Post-operative Surgical Site Infections	January 2010	Not Applicable
NCT04899986	University of Pavia	Peri-implant Mucositis	May 15, 2021	Not Applicable
NCT05797818	Ondine Biomedical Inc.	Healthcare Associated Infection\|Nosocomial Infection\|Surgical Site Infection	January 10, 2023	Phase 1\|Phase 2
NCT03384537	Cairo University	Dental Diseases	June 1, 2024	Early Phase 1
NCT01750801	Federal University of Minas Gerais	Gingivitis\|Periodontitis\|Plaque\|Inflammation	February 2013	Phase 3
NCT03484507	University of California, San Francisco\|Research to Prevent Blindness	Acanthamoeba Keratitis	January 1, 2018	Phase 2
NCT02202577	Case Western Reserve University	Surgical Site Infection	March 2014	Not Applicable
NCT05304338	Ataturk University	Oral Hygiene\|Dental Plaque	October 10, 2021	Not Applicable
NCT05254275	University of Pavia	Peri-implant Mucositis	March 22, 2022	Not Applicable
NCT02115776	University of Santiago de Compostela\|Hospital Clinico Universitario de Santiago	Bacteremia	January 2014	Not Applicable
NCT02624622	University of New Mexico\|University of Nairobi	Omphalitis	March 2015	Not Applicable
NCT01349192	University of North Carolina, Chapel Hill\|CF Therapeutics Development Network Coordinating Center\|Seattle Children´s Hospital\|Washington University School of Medicine\|University of Washington\|University of Colorado, Denver\|Baylor College of Medicine\|University of Alabama at Birmingham\|Cook Children´s Medical Center\|University of Michigan\|University of Florida\|University of Texas Southwestern Medical Center\|Children´s Hospital Medical Center, Cincinnati\|St. Louis Children´s Hospital	Cystic Fibrosis\|Methicillin-resistant Staphylococcus Aureus	April 2011	Phase 2
NCT01270776	Mount Sinai Hospital, Canada\|The Physicians´ Services Incorporated Foundation	Anti-infecting Agents, Local	January 2011	Not Applicable
NCT04385680	Zagazig University	Postpartum Endometritis\|Wound Infection\|Chlorhexidine Adverse Reaction\|Postoperative Fever	May 15, 2020	Phase 1\|Phase 2
NCT03431701	Makassed General Hospital	Vaginal Scrubbing	February 8, 2018	Not Applicable
NCT00006075	National Institute of Allergy and Infectious Diseases (NIAID)	HIV Infections		Phase 2
NCT04654182	Molnlycke Health Care AB\|BioScience Laboratories, Inc.	Hand Hygiene	November 30, 2020	Phase 4
NCT02589067	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center\|Thrasher Research Fund	S. Aureus Oropharyngeal Colonization	October 2015	Phase 2
NCT03571100	MidAtlantic Retina\|Wills Eye	Age-related Macular Degeneration\|Diabetic Vascular Diseases\|Proliferative Retinopathy\|Retina Vein Occlusion	May 7, 2018	Early Phase 1
NCT00608959	Cadence Pharmaceuticals\|Cadence	Infection	May 2008	Phase 3
NCT02402907	Icahn School of Medicine at Mount Sinai	Chlorhexidine Gluconate Cloths\|Infection; Cesarean Section\|Infectious Morbidity\|Surgical Site Infections\|Endometritis	April 2015	Not Applicable
NCT03348917	Mundipharma Manufacturing Pte Ltd.\|Genome Institute of Singapore	Skin Health	December 28, 2017	Phase 4
NCT03526770	Dr Meru S\|Uttaranchal Dental & Medical Research Institute	Saliva Altered\|Oral Hygiene\|pH\|Tooth Structure; Disorder	May 28, 2018	Not Applicable
NCT01886001	University of Virginia	Colonization	November 2012	Not Applicable
NCT04430998	University of Milan\|Azienda Farmaceutica Italiana SRL	Periodontal Index\|Pain	June 2020	Phase 3
NCT02153658	Ministry of Health, Rwanda	Odor Levels of Study Arms	November 2013	Not Applicable
NCT02753387	Rennes University Hospital	Bacterial Infection	May 23, 2016	Phase 3
NCT05312606	University of Pavia	Periodontal Diseases	April 4, 2022	Not Applicable
NCT02282605	Destiny Pharma Plc	Staphylococcus Aureus Infection	September 2014	Phase 1\|Phase 2
NCT01382446	St. Joseph´s Hospital and Medical Center, Phoenix\|3M	Ventilator Associated Pneumonia	July 2010	Not Applicable
NCT04032548	Mahsa University	Gingivitis	February 18, 2019	Not Applicable
NCT05069246	Ishrat Rahman\|Princess Nourah Bint Abdulrahman University	Gingivitis	December 8, 2020	Phase 2
NCT02545244	Sri Hasanamba Dental College and Hospital	Gingivitis	February 2015	Phase 3
NCT02032394	Mashhad University of Medical Sciences	Urinary Tract Infection\|Nosocomial Infection\|Bacteriuria	July 2013	Phase 4
NCT02949583	Universidade Estadual da Paraiba	Gingivitis	March 2012	Not Applicable
NCT05548361	Cukurova University\|BioGaia AB\|Sunstar	Periodontitis\|Chlorhexidine\|Probiotic	April 1, 2022	Not Applicable
NCT01883596	Sinaloa Pediatric Hospital	Mechanical Ventilation for More Than 48 Hours.	October 2012	Phase 4
NCT03119831	National and Kapodistrian University of Athens	Periodontitis\|Wound Healing	November 2015	Not Applicable
NCT03700749	University of Birmingham\|Lagos State University\|Universidad Francisco Marroquín\|Kigali University Teaching Hospital\|Christian Medical College and Hospital, Ludhiana, India\|University of Edinburgh\|University of the Philippines\|King Edward Medical University\|University of Witwatersrand, South Africa\|Universidad Peruana Cayetano Heredia\|Centre National Hospitalier Universitaire\|Ndola Teaching Hospital\|Hospital Espanol de Veracruz\|Tamale Teaching Hospital, Tamale	Abdominal Surgery\|Surgical Site Infection	November 29, 2018	Phase 3
NCT00259181	Hadassah Medical Organization	Dental Plaque	January 2005	Phase 1
NCT01852253	University Medical Center Groningen	Periodontal Diseases\|Peri-implantitis	March 2010	Not Applicable
NCT00223002	University of Saskatchewan	Asepsis\|Analgesia, Epidural\|Anesthesia, Epidural	November 2004	Not Applicable
NCT04485520	Julieta María Méndez Romero\|Universidad Nacional de Caaguazu	Streptococcus, Other Specified Group\|Dental Plaque	September 21, 2017	Not Applicable
NCT04884464	University of Urbino Carlo Bo	Aphthous Stomatitis	September 1, 2018
NCT02560870	Islamic Azad University, Tehran	Periodontal Diseases	March 2014	Phase 2\|Phase 3
NCT00234598	Virginia Commonwealth University\|National Institute of Nursing Research (NINR)	Ventilator Associated Pneumonia	March 2002	Phase 2
NCT00682006	Aga Khan University\|John Snow, Inc.	Omphalitis	January 2008	Phase 3
NCT02223520	Johns Hopkins University\|Agency for Healthcare Research and Quality (AHRQ)	Staph Aureus Colonization\|Staph Aureus Infection	November 2014	Not Applicable
NCT00549393	Johns Hopkins University\|Sage Products, Inc.	Nosocomial Infections	February 2008	Phase 2\|Phase 3
NCT02709824	University of Milan	Adverse Effect	December 2011	Not Applicable
NCT03118232	University of California, Irvine\|Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center\|University of Massachusetts, Amherst\|Agency for Healthcare Research and Quality (AHRQ)	Hospitalization\|Infection	April 3, 2017	Phase 4
NCT04756804	Zurex Pharma, Inc.	Surgical Site Infection	June 21, 2021	Phase 3
NCT05122169	Seoul National University Hospital	Vaginal Delivery\|Surgical Site Infection	December 2021	Not Applicable
NCT03331263	Medline Industries	Surgical Skin Preparation	July 21, 2017	Phase 1
NCT02337192	University of Sao Paulo	Dentist-Patient Relations	January 2014	Phase 1
NCT02097615	Universidad de Guanajuato\|National Council of Science and Technology, Mexico	Soft Tissue Infections	May 2014	Phase 4
NCT04954313	University of North Carolina, Chapel Hill\|Colgate Palmolive	Cardiovascular Diseases\|Diabetes Type 2	September 28, 2021	Phase 4
NCT05841589	omnia sayed\|Ain Shams University	Dental Caries	February 21, 2018	Not Applicable
NCT02080403	Dexcel Pharma Technologies Ltd.	Peri-Implantitis	July 2014	Phase 3
NCT02513784	Columbia University	Esophageal Adenocarcinoma\|Barrett´s Esophagus\|Reflux Esophagitis	August 2015	Not Applicable
NCT04830969	State University of New York at Buffalo\|Sunstar, Inc.	Diabetes Mellitus, Type II\|Periodontitis	November 8, 2016	Phase 2
NCT01720797	University of Florida\|AlevoLogic LLC	Malocclusion	February 2013	Not Applicable
NCT03731780	Cairo University	Dental Caries	December 2018	Not Applicable
NCT03305159	Northwestern University	Surgical Preparation of the Vagina	August 1, 2017	Phase 4
NCT05312593	University of Pavia	Peri-implant Mucositis	April 5, 2022	Not Applicable
NCT04399161	Dr. Krupa NC\|JSS Dental College And Hospital	Cariostatic Agents\|Mouthwashes	February 15, 2017	Phase 2\|Phase 3
NCT01030666	Peter Eickholz\|Heidelberg University\|Dr. August Wolff GmbH & Co. KG Arzneimittel\|Gaba International AG\|Goethe University	Periodontitis	April 2007	Phase 4
NCT02131922	Jagiellonian University	Periodontitis\|Hypertension	September 2009	Not Applicable
NCT00528008	Memorial University of Newfoundland\|Eastern Health	Wound Infection	December 2007	Phase 3
NCT01919593	Thammasat University	Bacteremia	January 2012	Phase 4
NCT05187663	University of Belgrade\|Military Medical Academy\|Bredent Medical, Helbo	Peri-Implantitis	January 2014	Not Applicable
NCT02433899	Universidade Federal Fluminense	Gingival Recession	October 2010	Phase 4
NCT00136370	Centers for Disease Control and Prevention\|Bill and Melinda Gates Foundation\|United States Agency for International Development (USAID)\|National Vaccine Program Office	Infant, Newborn, Diseases\|Sepsis\|Puerperal Infection	April 2004	Phase 3
NCT00121394	NICHD Global Network for Women´s and Children´s Health\|Global Network for Women´s and Children´s Health Research\|Bill and Melinda Gates Foundation\|RTI International\|University of Alabama at Birmingham\|Aga Khan University\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Sepsis\|Pregnancy	June 2005	Phase 3
NCT03431766	G. d´Annunzio University	Bone Resorption\|Bacteria Caused Disease	November 17, 2015	Not Applicable
NCT02375178	Universidade do Vale do Sapucai	Periimplantitis\|Dental Plaque\|Periodontal Diseases\|Caries\|Oral Surgical Wound Infection	August 2014	Not Applicable
NCT03957291	Assiut University	Disinfectant Causing Toxic Effect	August 2019	Early Phase 1
NCT05707221	University of Baghdad	Oral Disease	April 17, 2022	Not Applicable
NCT00597688	All India Institute of Medical Sciences, New Delhi	Ventilator Associated Pneumonia	November 2007	Phase 3
NCT03836781	Amirhossein Farahmand\|Islamic Azad University, Tehran	Chronic Periodontitis	April 10, 2018	Phase 2\|Phase 3
NCT00560599	Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center\|Kaiser Permanente	Methicillin Resistant Staphylococcus Aureus Skin Infections	April 2007	Phase 3
NCT00475930	Uniformed Services University of the Health Sciences	Staphylococcus Aureus\|Community-Acquired Infections\|Staphylococcal Skin Infections	May 2007	Not Applicable
NCT02414581	Hospital Regional de Alta Especialidad del Bajio\|Universidad de Guanajuato	Neutropenia	April 2015	Phase 3
NCT03787082	Gladwin, Mark, MD\|National Institutes of Health (NIH)\|National Heart, Lung, and Blood Institute (NHLBI)\|University of Pittsburgh	Pulmonary Hypertension\|Heart Failure With Normal Ejection Fraction\|Pulmonary Heart Disease and Diseases of Pulmonary Circulation	December 2022	Phase 1
NCT03142607	Aga Khan University	Gingivitis	February 3, 2017	Phase 3
NCT00271440	Johns Hopkins Bloomberg School of Public Health\|Tribhuvan University, Nepal\|Nepal Nutrition Intervention Project Sarlahi	Bacterial Infection	January 2006	Phase 1\|Phase 2
NCT00513799	Washington University School of Medicine	Abscesses\|Furunculosis\|Staphylococcus Aureus\|Staphylococcal Skin Infections	March 2007	Not Applicable
NCT01105767	Henry M. Jackson Foundation for the Advancement of Military Medicine\|Centers for Disease Control and Prevention	Staphylococcus Aureus\|MRSA Skin Infections\|Staphylococcal Skin Infections	May 2010	Not Applicable
NCT05258955	Liaquat National Hospital & Medical College\|Liaquat College of Medicine and Dentostry	Dental Plaque	June 3, 2020	Phase 1
NCT02894593	University of L´Aquila	Gingivitis\|Periodontitis	January 2015	Not Applicable
NCT02291601	Medline Industries	Surgery	October 2014	Phase 3
NCT02227485	Shiraz University of Medical Sciences	Gingivitis	July 2014	Not Applicable
NCT04446533	University of Milan\|BMG Pharma	Periodontitis\|Bleeding Gum\|Pocket, Periodontal	June 2020	Phase 3
NCT01580943	Universidade do Porto	Dental Plaque	October 2011	Phase 1\|Phase 2
NCT04235985	Molnlycke Health Care AB	General Skin Cleansing	January 23, 2020	Phase 4
NCT02279381	Aga Khan University\|University of Sydney\|The International Federation of Red Cross and Red Crescent Societies	Neonatal Infections	November 2014	Phase 4
NCT03401749	University of Alabama at Birmingham	Surgical Site Infection	November 1, 2018	Phase 4
NCT03773094	Cairo University	High Caries Risk Patients\|Antimicrobial Effect\|Salivary pH\|Patient Satisfaction to Taste	January 2019	Phase 2\|Phase 3
NCT04868513	Biochemical and Microbiology Laboratory, Faculty of Dentistry, Autonomous University of San Luis Pot	Pregnant Women	January 2015	Phase 4
NCT02391714	University of New Mexico\|Society of Family Planning	Contraception	October 2013	Not Applicable
NCT03977324	Università Vita-Salute San Raffaele	Peri-Implantitis	July 2, 2018	Not Applicable
NCT02640469	NYU Langone Health	Infection	December 2016	Not Applicable
NCT03550651	Government College of Dentistry, Indore	Mild Gingivitis\|Periodontal Diseases\|Plaque	August 2016	Not Applicable
NCT00002431	Procter and Gamble\|NIH AIDS Clinical Trials Information Service	Candidiasis, Oral\|HIV Infections		Not Applicable
NCT02939092	Cairo University	Gingival Bleeding	January 2018	Not Applicable
NCT02446158	E-DA Hospital	Peritoneal Dialysis Catheter Exit Site Infection	May 2010	Phase 4
NCT03700788	University of Southern California	Apical Periodontitis	May 30, 2023	Phase 3
NCT02560155	Lindenhofgruppe AG\|Clinical Trials Unit Bern (CTU)\|Lindenhofstiftung\|Labormedizinisches Zentrum Dr. Risch	Orthopedic Disorders\|Surgical Site Infection	November 2015	Not Applicable
NCT04403971	National Cheng-Kung University Hospital	Hospital-acquired Pneumonia	May 25, 2020	Not Applicable
NCT03533166	Universidad Complutense de Madrid\|Dentaid SL	Peri-implant Mucositis	November 4, 2015	Not Applicable
NCT03009006	Cairo University	Necrotic Pulp	January 3, 2017	Not Applicable
NCT03915665	Istituto Ortopedico Galeazzi	Peri-implant Mucositis	April 15, 2019	Not Applicable
NCT01902446	Nicholas M Mohr\|University of Iowa	Wounds and Injuries\|Respiratory Failure\|Pneumonia, Ventilator-Associated	July 2013
NCT00130221	Cook County Health\|Sage Products, Inc.\|Centers for Disease Control and Prevention	Nosocomial Infection\|Bacteremia\|Sepsis\|Pneumonia\|Urinary Tract Infection\|Clostridium Infection	June 2005	Phase 1
NCT04438421	University of Milan	Gingivitis\|Bleeding Gum	June 2020	Phase 3
NCT04656145	NYU Langone Health	Drain Site Complication	January 1, 2021	Not Applicable
NCT00765167	Colgate Palmolive	Dental Plaque	November 2007	Phase 3
NCT00066950	University of California, San Francisco\|San Ysidro Health Center\|University of California, San Diego\|San Diego State University	Dental Caries	March 2003	Phase 3
NCT05110001	University of California, San Francisco\|Aravind Eye Care System\|National Eye Institute (NEI)\|Stanford University\|Federal University of São Paulo	Acanthamoeba Keratitis\|Fungal Keratitis	August 3, 2022	Phase 3
NCT04505202	Karabuk University	Ventilator Associated Pneumonia\|Tracheobronchitis	April 15, 2019	Not Applicable
NCT05206721	Mansoura University	Ventilator Associated Pneumonia	May 10, 2020	Early Phase 1
NCT02915289	Richmond University Medical Center	Wound Infection\|Complication, Postoperative	December 2016	Phase 3
NCT02395614	Vanderbilt University Medical Center	Breast Cancer	December 2015	Not Applicable
NCT00266448	Heidelberg University	MRSA-Colonization	January 2001	Phase 2
NCT00417235	University Hospital, Grenoble\|Ministry of Health, France	Systemic Inflammatory Response Syndrome\|Bacteremia	January 2007	Phase 4
NCT04770792	King Abdulaziz University	Indirect Pulp Treatment	April 6, 2019	Not Applicable
NCT05828810	Sunnybrook Health Sciences Centre	Aseptic Revision Total Hip Arthroplasty\|Total Knee Arthroplasty With Exchange of at Least One Prosthetic Component	May 2023	Phase 4
NCT04483063	National Cheng-Kung University Hospital	C. Acnes\|Arthroscopic Rotator Cuff Repair	March 23, 2020	Not Applicable
NCT03588351	Ain Shams University	Necrotic Pulp	January 1, 2018	Not Applicable
NCT02154594	Tatyasaheb Kore Dental College	Gingivitis	February 2014	Phase 4
NCT03871777	University of Plymouth\|University of the West of Scotland	Blood Pressure	May 9, 2016	Not Applicable
NCT05441605	Aydin Adnan Menderes University	Catheter-Associated Infections	June 24, 2022	Not Applicable
NCT03594513	Universidade Estadual Paulista Júlio de Mesquita Filho\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Gingival Recession\|Tooth Abrasion	July 2, 2018	Not Applicable
NCT02065414	Johnson & Johnson Consumer and Personal Products Worldwide	Gingivitis	March 2014	Phase 4
NCT01014143	Colgate Palmolive	Dental Plaque	August 2007	Phase 2
NCT02326467	Celeste Chandonnet\|Boston Children´s Hospital	Chlorhexidine Allergy\|Infection\|Rash	February 2016	Phase 1
NCT02126267	Centro Universitario de Lavras\|Federal University of Minas Gerais	Periodontal Disease\|Chronic Periodontitis	January 2013	Not Applicable
NCT04512638	Tim Van den Wyngaert\|Kom Op Tegen Kanker\|University Hospital, Antwerp	Medication Related Osteonecrosis of the Jaw	January 1, 2021	Phase 4
NCT01521260	University Medical Center Groningen	Peri-implantitis\|Periodontal Disease	October 2009	Not Applicable
NCT03669224	Cairo University	Caries Class Ii	November 1, 2019	Phase 1
NCT05855616	Hospital Universitario Marqués de Valdecilla	Hemodialysis Catheter Infection	November 1, 2020	Not Applicable
NCT00972803	Tabriz University	Gingivitis	May 2008	Phase 2
NCT04009616	Damascus University	Oral Health	March 1, 2019	Not Applicable
NCT05971810	Peking Union Medical College Hospital\|Fujian Provincial Hospital\|The Second Hospital of Hebei Medical University\|Shenzhen Qianhai Shekou Free Trade Zone Hospital\|Ningbo No.2 Hospital\|Peking University International Hospital	Postoperative Complications\|Pulmonary Complication	August 1, 2023	Not Applicable
NCT05974124	Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia\|European School of Advanced Studies in Ophthalmology	Antiseptics\|Microbiota\|Conjunctiva	November 9, 2022	Not Applicable
NCT00731783	Washington University School of Medicine	Staphylococcal Skin Infections\|Abscesses\|Furunculosis\|Staphylococcus Aureus\|MRSA Infection	July 2008	Not Applicable
NCT01962493	GlaxoSmithKline	Oral Hygiene	September 2013	Phase 4
NCT02709785	St. Louis University\|Triumph Pharmaceuticals	Gingivitis\|Periodontitis	March 2016	Not Applicable
NCT03442023	Universidad de Guanajuato	Chlorhexidine\|Ventilator Associated Pneumonia	February 1, 2019	Phase 3
NCT00448942	Hunter Holmes Mcguire Veteran Affairs Medical Center\|Weill Medical College of Cornell University\|Washington University School of Medicine\|Johns Hopkins University\|University of Tennessee\|Centers for Disease Control and Prevention	Nosocomial Bacteremia\|Nosocomial Fungemia\|MRSA Colonization\|MRSA Infection\|VRE Colonization\|VRE Infection	November 2004
NCT00779246	Christiana Care Health Services\|Sage Products, Inc.	Staphylococcal Infections	June 2008	Not Applicable
NCT03372122	Caroline Scott\|Molnlycke Health Care AB	General Skin Cleansing	December 13, 2017	Phase 4
NCT01361997	Universidad de Guanajuato	Infectious Diseases	June 2011	Phase 3
NCT00896402	Northwell Health	Infection	July 2014	Not Applicable
NCT03883828	Montefiore Medical Center	Radiation Dermatitis	June 3, 2019	Phase 2\|Phase 3
NCT01410682	Federal University of São Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Tracheal and Oropharyngeal Colonization by Gram-negative Pathogens	June 2005	Not Applicable
NCT02219776	McLaren Health Care	Post Operative Infection Arthroscopic Shoulder Surgery\|Infection	September 2015	Not Applicable
NCT03003871	The University of Hong Kong\|Tung Wah Hospital	Stroke	April 2013	Not Applicable
NCT03141554	Mundipharma Manufacturing Pte Ltd.\|Singapore Polytechnic (SP)	Oral Health	May 5, 2017	Phase 4
NCT02132546	dott. Lorenzo Bevilacqua\|University of Trieste	Staining Effect of Chlorhexidine	February 2011	Phase 2
NCT02029872	Johns Hopkins University\|Robert Wood Johnson Foundation	MRSA	January 2014	Phase 4
NCT01992198	Erzhen Chen\|RenJi Hospital\|Ruijin Hospital	Pancreatitis,Acute Necrotizing	July 2012	Phase 4
NCT02222896	Medline Industries	Surgery	August 2014	Phase 3
NCT02396329	Ain Shams Maternity Hospital	Surgical Site Infection	June 2014	Phase 2
NCT03513575	Dr Meru S\|Uttaranchal Dental & Medical Research Institute	Saliva Altered\|Oral Hygiene\|pH\|Tooth Structure; Disorder	May 1, 2018	Not Applicable
NCT03030989	University of Chicago	Stem Cell Transplant Complications	January 2017	Phase 2
NCT01036412	M.D. Anderson Cancer Center	Head and Neck Cancer	December 2009	Phase 1
NCT02077920	General Hospital of Shenyang Military Region	Ventilator-associated Pneumonia	March 2014	Phase 2
NCT02537964	Shaare Zedek Medical Center	Infectious Disease Transmission	September 2016	Not Applicable
NCT00785200	University of Chicago\|University of Texas Southwestern Medical Center\|Sage Products, Inc.	Methicillin-resistant Staphylococcus Aureus\|Skin Diseases, Infectious\|Soft Tissue Infections	January 2009	Not Applicable
NCT00841074	University of Louisville\|National Institute of Dental and Craniofacial Research (NIDCR)	Pneumonia\|Respiratory Infection	January 2006	Phase 1
NCT02391077	Ministry of Health, Rwanda	Disease Due to Gram-positive Bacteria	April 2015	Phase 1
NCT04607785	Al-Iraqia University	Gingivitis	January 15, 2020	Early Phase 1
NCT01241318	Boston University\|Bill and Melinda Gates Foundation\|Ministry of Health, Zambia\|Zambia Center for Applied Health Research and Development	Sepsis	February 2011	Phase 2\|Phase 3
NCT02943759	Cairo University	Periapical Abscess	December 1, 2016	Phase 2\|Phase 3
NCT03492827	Peking University Third Hospital	Esophageal Cancer\|Gastric Cancer	June 1, 2017	Not Applicable
NCT04344236	NYU Langone Health	COVID-19	April 9, 2020	Phase 2
NCT03423147	Angela Bianco\|Stryker Nordic\|Icahn School of Medicine at Mount Sinai	Cesarean Section\|Surgical Site Infection\|Nosocomial Infection	October 5, 2018	Phase 2
NCT02469311	LifeBridge Health	Osteoarthritis\|Infection	March 2012	Phase 2
NCT04719208	Augusta University	Covid19	October 6, 2020	Not Applicable
NCT03813693	University of Sao Paulo	Surgical Site Infection	May 2, 2017	Not Applicable
NCT01898000	Government Dental College and Research Institute, Bangalore	Gingivitis	January 2013	Not Applicable
NCT04171817	Johns Hopkins Bloomberg School of Public Health\|Children´s Hospital of Philadelphia\|University of Pennsylvania\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Methicillin-resistant Staphylococcus Aureus\|Clostridium Difficile\|Pseudomonas Aeruginosa	May 1, 2023	Phase 4
NCT00867035	University of California, San Francisco	Halitosis	March 2008	Not Applicable
NCT02605382	Universidade Federal do Rio Grande do Norte	Mucositis	October 2012	Phase 2
NCT04942496	Molnlycke Health Care AB\|BioScience Laboratories, Inc.	Skin Irritancy Potential	June 2021	Phase 4
NCT01425697	University of Rochester\|Sage Products, Inc.	Surgical Site Infections	November 2008	Not Applicable
NCT03844776	Taibah University	Infection	October 2, 2019	Not Applicable
NCT03133312	Metro Health, Michigan	Infection, Bacterial	May 2, 2017	Phase 4
NCT00502476	Hunter Holmes Mcguire Veteran Affairs Medical Center\|Centers for Disease Control and Prevention\|Sage Products, Inc.	Nosocomial Bacteremia\|MRSA Colonization\|MRSA Infection\|VRE Colonization\|VRE Infection	August 2007
NCT04781478	University of Pavia	Periodontal Diseases	March 16, 2021	Not Applicable
NCT03166163	Cairo University	Gingival Bleeding	May 20, 2017	Not Applicable
NCT04027179	University of Taubate\|Conselho Nacional de Desenvolvimento Científico e Tecnológico	Periodontitis\|Normal Blood Pressure	August 2020	Phase 4
NCT04021524	University of Washington	Propionibacterium Acnes	September 10, 2018	Phase 4
NCT00109616	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|United States Agency for International Development (USAID)\|Bill and Melinda Gates Foundation	Neonatal Mortality	October 2002	Phase 3
NCT00067340	University of Washington\|National Institute of Dental and Craniofacial Research (NIDCR)	Dental Caries	April 2003	Phase 3
NCT04218799	University of Maryland, Baltimore\|VA Office of Research and Development	Human Microbiome	August 12, 2014	Phase 4
NCT05430308	Postgraduate Institute of Medical Education and Research	Medical Thoracoscopy	April 18, 2022	Not Applicable
NCT05485051	Hospital do Coracao\|Hospital Sírio-Libanês\|Hospital Israelita Albert Einstein\|Hospital Moinhos de Vento\|Hospital Alemão Oswaldo Cruz\|A Beneficência Portuguesa de São Paulo	Health Care Associated Infection\|Ventilator Associated Pneumonia\|Central Line-associated Bloodstream Infection (CLABSI)\|Catheter-Associated Urinary Tract Infection	August 3, 2022	Phase 3
NCT02572791	Washington University School of Medicine	Skin and Subcutaneous Tissue Bacterial Infections\|Staphylococcus Aureus\|MRSA - Methicillin Resistant Staphylococcus Aureus Infection	October 2015	Phase 4
NCT01955317	International Centre for Diarrhoeal Disease Research, Bangladesh\|State University of New York at Buffalo	Hand Washing Behavior\|Hand Cleansing Behavior\|Chlorhexidine\|Neonatal Period	October 2013	Not Applicable
NCT01947192	Federal University of Pelotas	Non-carious Cervical Lesions	November 2011	Not Applicable
NCT03955341	Misr International University	Patients With Deep Carious Lesions	October 20, 2019	Not Applicable
NCT04256798	University of Birmingham	Infection\|Pneumonia\|Surgical Site Infection\|Wound Infection\|Surgical Wound Infection\|Postoperative Complications\|Anesthesia\|Communicable Disease\|Pathologic Processes\|Perioperative Complication\|Chlorhexidine\|Laparotomy	November 13, 2020	Phase 3
NCT00004640	University of Washington\|National Institute of Dental and Craniofacial Research (NIDCR)\|Colgate Palmolive	Tooth Loss\|Periodontal Disease\|Tooth Decay	May 1998	Phase 3
NCT03014778	HaEmek Medical Center, Israel	Vaginal Surgeries	January 1, 2017	Phase 4
NCT02062047	University of Guarulhos	Periodontitis\|Diabetes	December 2007	Phase 4
NCT03719404	Postgraduate Institute of Dental Sciences Rohtak	Root Canal Infection	October 2016	Not Applicable
NCT00859235	Hillel Yaffe Medical Center	Dysphagia\|Peristomal Wound Infection	May 2009	Phase 3
NCT04527276	Istanbul Medeniyet University	Ventilator Associated Pneumonia	February 1, 2019	Not Applicable
NCT01594827	Johns Hopkins University\|Case Western Reserve University\|Cystic Fibrosis Foundation	Cystic Fibrosis	October 2012	Phase 2
NCT05919966	National Taiwan University Hospital	Central Line-associated Bloodstream Infection (CLABSI)	April 12, 2023
NCT02833376	Universidade do Vale do Sapucai	Anesthesia, Spinal\|Anesthesia, Epidural\|Antisepsis	May 30, 2016	Not Applicable
NCT04032184	Cairo University	Prevention of Dental Caries	October 1, 2019	Not Applicable
NCT04202471	Northwell Health	Surgical Site Infection	March 1, 2020	Not Applicable
NCT03475394	KLE VK Institute of Dental Sciences	Chronic Periodontitis	January 2015	Not Applicable
NCT02490631	Vanderbilt University\|Sage Products, Inc.\|Vanderbilt University Medical Center	Surgical Site Infections\|Post Operative Complication	August 2015	Phase 3
NCT01613365	Assistance Publique Hopitaux De Marseille	Infections and Respiratory Infectious	May 2012	Phase 3
NCT01382914	Technische Universität Dresden	Discoloration of Teeth	April 2011	Not Applicable
NCT04679558	Cairo University	Caries	September 15, 2020	Early Phase 1
NCT05844683	Okan University	Health Care Associated Infection\|Skin	September 1, 2022	Not Applicable
NCT04516226	Albany Medical College	Preterm Premature Rupture of Membrane	August 1, 2020	Not Applicable
NCT01857804	Göteborg University\|The Swedish Research Council	Peri-Implantitis	January 2013	Phase 4
NCT01105819	Region Skane\|County Council of Halland, Sweden\|Probi AB	Pathogenic Bacteria in the Oropharynx\|Ventilator-associated Pneumonia	April 2010	Not Applicable
NCT05361278	Damascus University	Dental Caries\|Infection, Bacterial\|Tooth, Deciduous	January 15, 2021	Not Applicable
NCT02950246	Hôpital Raymond Poincaré	Infection of Catheter Exit Site\|Catheter Related Infection	November 2016	Not Applicable
NCT03438890	Kangbuk Samsung Hospital	Gynecologic Disease	April 23, 2018	Not Applicable
NCT01216761	University of Michigan\|Blue Cross Blue Shield of Michigan Foundation	Bacteremia	May 2008	Not Applicable
NCT05803590	Cairo University	Plaque Induced Gingivitis	May 1, 2023	Not Applicable
NCT01657396	University of Calgary\|Sage Products, Inc.	Ventilator Associated Pneumonia\|Oral Hygiene	July 2012	Not Applicable
NCT05952921	Universidad El Bosque, Bogotá	Periodontal Diseases\|Chronic Periodontitis\|Microbial Colonization	July 10, 2019	Not Applicable
NCT01154530	Herlev Hospital\|Bispebjerg Hospital\|University Hospital, Gentofte, Copenhagen	Gastroscopy	January 2011	Not Applicable
NCT01528852	Johns Hopkins Bloomberg School of Public Health\|Annamalai University\|Ministry of Health and Social Welfare, Zanzibar	Neonatal Mortality\|Cord Care\|Omphalitis	October 2010	Phase 3
NCT04225065	Mark Seeley\|Geisinger Clinic	Arm Fracture\|Surgical Site Infection	June 17, 2020	Phase 4
NCT04074915	Institute of Dental Sciences, Bareilly, Uttar Pradesh, India	Chronic Periodontitis	December 20, 2018	Not Applicable
NCT05059145	Karolinska Institutet	Candidiasis, Vulvovaginal	April 27, 2022	Phase 2
NCT05920122	University of Pittsburgh	Surgical Site Infection\|Cesarean Section; Infection	July 1, 2023	Phase 4
NCT04683146	Centro Ortopedico y Quirurgico del Pie	Antisepsis	March 10, 2021	Phase 4
NCT05024760	Madigan Army Medical Center\|United States Department of Defense	Peri-Implantitis\|Peri-implant Mucositis\|Implant Infection\|Dental Implant Failed	July 28, 2022	Early Phase 1
NCT05963711	Hadassah Medical Organization	Bacterial Vaginosis\|Microbial Colonization	October 17, 2022	Not Applicable
NCT05913856	National Taiwan University Hospital	Ventilator Associated Pneumonia	January 4, 2022	Not Applicable
NCT04723446	Queen Mary University of London\|GlaxoSmithKline	Covid19\|Coronavirus	May 19, 2021	Not Applicable
NCT00759187	Colgate Palmolive	Gingival Diseases	January 2008	Phase 3
NCT03174756	Universidad El Bosque, Bogotá	Hypochlorous Acid\|Mouthwashes	January 15, 2015	Phase 2
NCT00198679	Johns Hopkins Bloomberg School of Public Health	Skin Diseases, Infectious	March 2004	Phase 4
NCT04218110	Professional Disposables International, Inc.	Surgical Site Infection	February 11, 2020	Phase 3
NCT00248300	Virginia Commonwealth University\|United States Department of Defense\|Uniformed Services University of the Health Sciences\|TriService Nursing Research Program	Pneumonia	August 2005	Phase 4
NCT04223076	University of Oslo	Periodontal Diseases\|Periodontitis\|Dental Plaque	March 20, 2019	Phase 4
NCT00123123	State University of New York at Buffalo\|National Institute of Dental and Craniofacial Research (NIDCR)	Pneumonia	March 2004	Phase 2
NCT03614429	Cairo University	Penile Prosthesis; Complications	June 1, 2018	Phase 2
NCT03115892	Cairo University	Halitosis	April 1, 2017	Phase 1\|Phase 2
NCT01495117	Seung Duk Lee\|National Cancer Center, Korea	Surgical Site Infection	October 2011	Phase 3
NCT02033187	Vanderbilt University	Healthcare Associated Infections	July 2012	Phase 4
NCT05709015	University of Ljubljana	Gingivitis	January 5, 2023	Phase 2
NCT03741894	University of Pecs	Alveolitis of Jaw\|Alveoli, Teeth; Inflammation\|Dry Socket\|Impacted Third Molar Tooth	September 1, 2018	Phase 4
NCT05016713	Cairo University	S.Mutans Colonization in Adults With Fixed Orthodontic Appliance	June 1, 2021	Not Applicable
NCT03173053	Radboud University Medical Center\|ZonMw: The Netherlands Organisation for Health Research and Development\|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|University College, London	Staphylococcus Aureus\|Motility Disorder	February 8, 2018	Not Applicable
NCT02479347	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano	Wound Infection\|Breast Neoplasms	March 2013	Phase 4
NCT04603794	Ohio State University	COVID-19	October 1, 2020	Phase 4
NCT04723732	King Abdulaziz University	Gingivitis\|Dental Plaque	August 15, 2017	Not Applicable
NCT01751178	GlaxoSmithKline	Gingivitis	October 2012	Phase 4
NCT04718922	Seoul National University Hospital	Endobronchial Ultrasound	January 20, 2021	Phase 4
NCT05870059	Ziauddin University	Periodontal Diseases	February 2, 2022	Phase 2
NCT02095535	University of British Columbia	Drying Time	April 2014
NCT03940729	Lund University	Intravenous Drug Abuse, S Aureus Colonization	December 15, 2016	Phase 4
NCT03001102	Federal University of Minas Gerais\|Fundação de Amparo à Pesquisa do estado de Minas Gerais	Surgical Wound Infection	August 2015	Not Applicable
NCT04821193	Istanbul University - Cerrahpasa (IUC)	Disinfectant Dye Adverse Reaction\|Catheter-Related Infections\|Nursing Caries\|Children, Only\|Skin Lesion\|Chlorhexidine Adverse Reaction\|Catheter	November 7, 2017	Not Applicable
NCT01537783	Tufts Medical Center	Cutaneous Abscess	September 2011	Phase 4
NCT02150031	University of Santiago de Compostela	Bacteremia\|Tooth Extraction Status Nos	December 2010	Phase 4
NCT00612469	Universidade Federal do Ceara	Dental Caries	October 2005	Not Applicable
NCT03064191	rayan rabie dahab\|Cairo University	Postoperative Pain\|Pain, Dental	September 2017	Not Applicable
NCT05256914	University of Pavia	Peri-implant Mucositis	February 27, 2022	Not Applicable
NCT03103204	University of Taubate	Obese\|Obesity, Morbid\|Periodontitis	January 21, 2017	Phase 4
NCT05211622	University of Palermo	Mucositis (MeSH Unique ID: D052016)\|Stomatitis (MeSH Unique ID: D013280)	March 10, 2022	Phase 4
NCT01024738	Colgate Palmolive	Dental Plaque	March 2008	Phase 3
NCT02678104	Riyadh Colleges of Dentistry and Pharmacy	Dry Socket	October 2016	Phase 2
NCT02695901	Universidade Federal de Santa Maria\|Centro Universitário Franciscano	Dental Plaque	March 2016	Phase 4
NCT05816512	Ahmed Yousif Mahdi\|University of Baghdad	Dental Caries\|Gingivitis\|Periodontitis	April 1, 2023	Not Applicable
NCT00980980	Harvard Pilgrim Health Care\|Agency for Healthcare Research and Quality (AHRQ)\|Centers for Disease Control and Prevention\|Hospital Corporation of America\|University of California, Irvine\|Department of Population Medicine, Harvard Medical School + Harvard Pilgrim Healthcare Institute	Methicillin-resistant Staphylococcus Aureus	September 2009	Not Applicable
NCT03105960	Cairo University	Gingival Bleeding	March 10, 2017	Not Applicable
NCT01782573	Changhua Christian Hospital	Liver Tumors	October 2011	Phase 4
NCT02990013	University of Miami	Cleaning Product Causing Toxic Effect	December 1, 2018	Early Phase 1
NCT03489629	University of North Carolina, Chapel Hill\|University of Washington\|Cook Children´s Medical Center\|Indiana University\|University of Michigan\|University of Texas Southwestern Medical Center\|St. Louis Children´s Hospital	Cystic Fibrosis	April 3, 2018	Phase 2
NCT02566928	Clinical Directors Network\|Rockefeller University\|Patient-Centered Outcomes Research Institute	Methicillin-Resistant Staphylococcus Aureus\|Recurrence\|Staphylococcal Skin Infections\|Antibiotic Resistance	October 2015	Phase 4
NCT01213550	Ege University	This Study Evaluated the Effectiveness of Chlorhexidine Mouthrinse on Subgingival Microbiota	March 2006	Phase 4
NCT02319668	GlaxoSmithKline	Dental Prophylaxis and Implant Surgery	February 1, 2015	Phase 4
NCT02502682	Jared Brooks\|Northwestern Medicine	Clostridium Difficile	July 2015	Phase 2
NCT01438515	Horizon Health Network	Methicillin-resistant Staphylococcus Aureus	August 2008	Not Applicable
NCT02546804	Government College of Dentistry, Indore	Gingivitis\|Periodontitis	June 2015	Not Applicable
NCT03474146	Government College of Dentistry, Indore	Periodontal Diseases\|Gingivitis\|Periodontitis	April 12, 2017	Not Applicable
NCT04365270	Ain Shams University	Reversible Pulpitis\|Pulpitis\|Caries,Dental\|Caries Class I\|Caries; Dentin\|Caries	January 15, 2019	Phase 3
NCT04274517	University of Southern California	Periprosthetic Joint Infection	January 16, 2021	Not Applicable
NCT03382730	University of Toronto\|Sunnybrook Health Sciences Centre\|Toronto General Hospital\|University Health Network, Toronto\|Unity Health Toronto\|MOUNT SINAI HOSPITAL	Mortality\|Oral Health\|Dryness, Mouth\|Pain, Orofacial	December 1, 2017	Not Applicable
NCT02767427	Columbia University\|Orthopaedic Scientific Research Foundation Inc	Infection\|Spinal Injuries	February 2016	Not Applicable
NCT02639377	Universidade Federal do Rio Grande do Norte	Mucositis\|Gingivitis	October 2012	Phase 2
NCT05254288	University of Pavia	Periodontal Diseases	March 22, 2022	Not Applicable
NCT00471783	University of British Columbia\|Canadian Foundation for Dental Hygiene Research and Education\|British Columbia Dental Hygienists´ Association (BCDHA)	Gingivitis	April 2006	Phase 3
NCT02479958	University of Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Dental Caries	May 2011	Phase 1
NCT03977285	Università Vita-Salute San Raffaele	Peri-Implantitis	July 2, 2018	Not Applicable
NCT00516360	National Institute of Allergy and Infectious Diseases (NIAID)\|University of Rochester	Catheterization	July 2007	Phase 4
NCT03684993	Cairo University	High Caries Risk Patients\|Caries\|Antimicrobial Effect\|Side Effect	December 10, 2019	Phase 2\|Phase 3
NCT04658225	Universidade Federal Fluminense	Age Problem	August 1, 2018	Not Applicable
NCT02433912	Universidade Federal Fluminense	Gingival Recession	June 2002	Phase 4
NCT04345744	University of Pisa	Periodontal Diseases\|Periodontal Pocket	January 2016	Not Applicable
NCT03977298	Università Vita-Salute San Raffaele	Peri-Implantitis	July 2, 2018	Not Applicable
NCT03574246	Ankara University	Sore Throat\|Nausea and Vomiting, Postoperative	January 10, 2018	Phase 4
NCT03838575	University of Birmingham\|National Institute for Health Research, United Kingdom\|University College, London	Surgical Site Infection\|Surgical Wound Infection\|Surgery--Complications\|Surgery	March 1, 2019	Phase 3
NCT05084378	Hamilton Health Sciences Corporation\|McMaster University	Periprosthetic Joint Infection\|Draining Wound	March 11, 2022	Phase 3
NCT01841242	Centre Hospitalier Universitaire de Saint Etienne\|Ministry of Health, France\|CareFusion	Heart Failure\|Arrhythmia	April 23, 2013	Phase 4
NCT00357877	Tufts University\|National Institute of Dental and Craniofacial Research (NIDCR)	Caries, Dental	July 2006	Phase 3
NCT01975805	University of Southern California	Pregnancy\|Cesarean Section	January 2010	Not Applicable
NCT02215473	University of Taubate\|Fundação de Amparo à Pesquisa do Estado de São Paulo\|Conselho Nacional de Desenvolvimento Científico e Tecnológico	Gingivitis\|Periodontitis	August 2013	Phase 4
NCT02911766	University of Oslo	Dental Plaque\|Gingivitis	November 2016	Phase 4
NCT05468099	University of Alberta	Risk Reduction\|Occupational Exposure\|Dentist-Patient Transmission	March 29, 2022	Not Applicable
NCT03209466	Universidad de Guanajuato	Diabetic Foot	May 11, 2017	Phase 4
NCT02608879	NYU Langone Health	Oral Mucositis\|Oral Cancer	March 2014	Not Applicable
NCT01723501	All India Institute of Medical Sciences, New Delhi\|Maulana Azad Medical College\|Vardhman Mahavir Medical College And Safdarjung Hospital	Neonatal Sepsis\|Neonatal Mortality Rate	November 2012	Phase 2\|Phase 3
NCT01870583	Montefiore Medical Center	Surgical Site Infection Following Cesarean Delivery	February 2013	Not Applicable
NCT01782404	Wellspect HealthCare	Bacteriuria, Intermittent Catheterization	January 2013	Not Applicable
NCT01115049	Federico II University	Oral Mucositis	February 2010	Phase 4
NCT04556708	Abant Izzet Baysal University	Periodontal Diseases	April 1, 2019	Not Applicable
NCT02096094	Universidad de Guanajuato\|G70 antisepsis	Bed Bathing	April 2014	Phase 4
NCT02208154	MJM Bonten\|Paris 12 Val de Marne University\|UMC Utrecht	ICU-ecology (Multidrug Resistant Bacteria)\|ICU-acquired Bacteraemia	December 1, 2013	Phase 3
NCT05916742	Universidade Estadual Paulista Júlio de Mesquita Filho	Gingival Recession	April 15, 2022	Not Applicable
NCT02870062	Universidad Autonoma de Nuevo Leon	Healthcare Associated Infections	August 2016	Phase 1
NCT02771704	Kuwait University	Dentine Caries	October 2015	Not Applicable
NCT03061916	Cairo University	Dental Caries	March 2017	Phase 3
NCT02216227	VA Office of Research and Development	Surgical Site Infection	April 1, 2014	Not Applicable
NCT03309137	Alison Fox-Robichaud\|Dr. Richard Whitlock\|Dr. Julian Owen\|Pamela Benoit, RN\|Hamilton Health Sciences Corporation	Infection\|Heart; Surgery, Heart, Functional Disturbance as Result\|Bacteremia	November 19, 2017	Not Applicable
NCT05052775	Ziauddin University	Dental Caries	October 20, 2020	Not Applicable
NCT01446874	Washington University School of Medicine	Post-operative Pneumonia\|Lung Cancer\|Esophageal Cancer	September 22, 2011	Phase 2\|Phase 3
NCT01640925	Joshua Swan\|Texas Southern University\|The Methodist Hospital Research Institute	Cross Infection\|Pneumonia, Ventilator-associated\|Catheter-related Infections\|Infection Due to Indwelling Urinary Catheter\|Surgical Wound Infection	July 2012	Not Applicable
NCT00636480	CareFusion	Topical Antisepsis	October 2007	Phase 3
NCT04941131	King Abdulaziz University	COVID-19	July 2021	Phase 4
NCT00012688	US Department of Veterans Affairs\|Colgate-Periogard-Dentsply\|VA Office of Research and Development	Diabetes Mellitus\|Poor Glycemic Control\|Peridontal Disease		Not Applicable
NCT05532241	University of Rijeka\|University of Ljubljana	Gingivitis\|Malocclusion	November 1, 2021	Phase 3
NCT05874882	University of Baghdad	Periodontitis	December 12, 2022	Early Phase 1
NCT02606565	Makerere University\|Centre For International Health	Omphalitis\|Septicaemia	July 2016	Phase 4
NCT00516906	3M\|University of Nebraska	Catheterization	October 2007	Phase 2\|Phase 3
NCT02598778	Montefiore Medical Center	Dental Caries	November 1, 2015	Phase 2
NCT03693066	Izmir Katip Celebi University	Ozone\|Caries	January 2017	Not Applicable
NCT03894839	Yuzuncu Y?l University	Candidiasis, Oral	October 26, 2017	Not Applicable
NCT02018094	Hull University Teaching Hospitals NHS Trust\|University of Hull	Wound Infection\|Amputation Wound	October 8, 2013	Phase 4
NCT00066040	New York University\|National Institute of Dental and Craniofacial Research (NIDCR)	Caries, Dental	January 2001	Not Applicable
NCT05787600	University of Baghdad	Plaque Induced Gingivitis\|Mouth Diseases\|Bleeding Gum\|Periodontal Diseases	March 3, 2023	Phase 3
NCT03962777	Baskent University	Gingivitis	February 9, 2019	Not Applicable
NCT02814279	Universidade Estadual Paulista Júlio de Mesquita Filho	Gingival Recession	February 2014	Not Applicable
NCT03209115	Cairo University	Postoperative Flare up	July 8, 2017	Early Phase 1
NCT03737201	Izmir Katip Celebi University\|The Scientific and Technological Research Council of Turkey	Deep Caries\|Ozone	January 1, 2017	Not Applicable
NCT03639363	University Of Perugia\|Fondazione Toscana Gabriele Monasterio	Hospital Infection	August 10, 2015	Phase 4
NCT04328753	University of Baghdad	Generalized Gingivitis	April 1, 2020	Phase 1\|Phase 2
NCT05039593	Aydin Adnan Menderes University	Oral Complications	July 5, 2021	Not Applicable
NCT00610324	King Edward Memorial Hospital	Nosocomial Pneumonia\|Healthcare-Associated Pneumonia\|Aspiration Pneumonia\|Ventilator-Associated Pneumonia	May 2004	Phase 4
NCT04575948	Misr International University	Plaque, Dental\|Antimicrobial\|Mouthwash\|Cytotoxicity	July 2023	Phase 2\|Phase 3
NCT01142934	Catholic University of the Sacred Heart\|3M\|Fondazione C.N.R.+Regione Toscana G. Monasterio, Pisa, Italy	Catheterization\|Infection	October 2009	Phase 4
NCT02547103	Chiang Mai University\|Health Systems Research Institute, Thailand	End Stage Renal Disease\|Peritoneal Dialysis	June 1, 2016	Phase 4
NCT01083407	Federal University of São Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Ventilator Associated Pneumonia	June 2005	Phase 1
NCT04733196	Plovdiv Medical University	Gingivitis	October 1, 2020	Not Applicable
NCT03553628	Moataz Gamal Ali Abdul-Maksoud Konsouh\|Cairo University	Caries, Dental\|Risk Reduction	August 1, 2018	Not Applicable
NCT02935322	University of Oslo\|Göteborg University	Periodontal Disease\|Dental Caries	September 2009	Phase 4
NCT03855527	Nourhan M.Aly\|Alexandria University\|University of Alexandria	Dental Caries	January 12, 2018	Phase 2
NCT02001311	King Abdulaziz University	Orthodontic Appliance Complication\|Dental Caries	January 2014	Phase 1
NCT03623048	Cairo University	Decay, Dental	March 2019	Not Applicable
NCT05846139	Tuscan Dental Institute	Periodontal Diseases	January 17, 2022	Not Applicable
NCT03510962	Dr Meru S\|Uttaranchal Dental & Medical Research Institute	Saliva Altered\|Oral Hygiene\|pH\|Tooth Structure; Disorder	April 25, 2018	Not Applicable
NCT05142969	Shanghai Zhongshan Hospital	Chlorhexidine\|Hospital-Acquired Infection\|Surgery\|Intensive Care Unit	December 1, 2021	Not Applicable
NCT02510144	University of Maryland, Baltimore	Shoulder Infection	August 2015	Not Applicable
NCT04658355	University of Arizona	Vaginal Flora Imbalance	December 15, 2020	Not Applicable
NCT04373018	Postgraduate Institute of Dental Sciences Rohtak	Periapical Periodontitis	December 1, 2019	Not Applicable
NCT00692484	CareFusion	Healthy	October 2007	Phase 3
NCT03142828	Universidad de Murcia	Periimplantitis	April 15, 2017	Phase 4
NCT00947518	All India Institute of Medical Sciences, New Delhi	Neonatal Sepsis\|Low Birth Weight	August 2005	Not Applicable
NCT05586776	University of California, Irvine\|University of California, Davis\|University of California, San Francisco\|University of Massachusetts, Amherst	Surgical Site Infection	January 17, 2023	Phase 4
NCT00908817	Soonchunhyang University Hospital	Tracheal Intubation	May 2008	Not Applicable
NCT01233050	University of Pennsylvania\|3M	Colorectal Surgery	December 2010	Not Applicable
NCT02124655	University of Santiago de Compostela\|Johnson & Johnson	Oral Biofilm\|Mouthwash\|Periodontitis	September 2012	Phase 4
NCT01989416	Mahidol University	Antibiotic Resistant Infection	December 2013	Phase 3
NCT03503370	VA Office of Research and Development	Diabetic Foot Ulcer	January 2, 2019	Phase 2
NCT01974401	Mashhad University of Medical Sciences	Severe Neutropenia\|Thrombocytopenia\|Chemotherapy\|Blood Dyscrasia Patients	January 2010	Phase 2
NCT01893060	University of Virginia	Line Insertion Site\|Central Line-associated Bloodstream Infection (CLABSI)	July 2013	Not Applicable
NCT03656588	Rothman Institute Orthopaedics	Propionibacterium Infection	April 16, 2018	Not Applicable
NCT01817075	Children´s Oncology Group\|National Cancer Institute (NCI)	Bacterial Infection\|Benign Neoplasm\|Malignant Neoplasm\|Methicillin-Resistant Staphylococcus Aureus Infection\|Myeloid Neoplasm\|Recurrent Childhood Acute Lymphoblastic Leukemia\|Recurrent Childhood Acute Myeloid Leukemia	November 4, 2013	Phase 3
NCT04373421	Yuzuncu Y?l University	Impacted Third Molar Tooth	August 15, 2018	Phase 4
NCT04721626	Medical College of Wisconsin	Head and Neck Cancer	January 6, 2021

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Solvent & Solubility

In Vitro:

H ₂ O : 100 mg/mL ( 111.39 mM ; Need ultrasonic)

DMSO : ≥ 38 mg/mL ( 42.33 mM )

* "≥" means soluble, but saturation unknown.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (111.39 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MedChemExpress (MCE).

References

[1] Wael E Shams, et al. Peritoneal Lavage Using Chlorhexidine Gluconate at the End of Colon Surgery Reduces Postoperative Intra-Abdominal Infection in Mice. J Surg Res. 2015 May 1;195(1):121-7.
[2] Yi-Ching Li, et al. Assessment of the cytotoxicity of chlorhexidine by employing an in vitro mammalian test system. Journal of Dental Sciences. Volume 9, Issue 2, June 2014, Pages 130-135.
[3] Hon-Yeung Cheung, et al. Differential actions of chlorhexidine on the cell wall of Bacillus subtilis and Escherichia coli. PLoS One. 2012;7(5):e36659.

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