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[CAS NO. 4643-58-7] Verrucarin J
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N10113 |
| Brand: | MCE |
| CAS: | 4643-58-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 484.54 |
| Molecular Formula | C27H32O8 |
| SMILES | CC1=C[C@@H]2[C@]3(COC(/C=C(C)/CCOC(/C=C/C=C\C(OC4[C@]3(C)[C@@]5([C@H](O2)C4)CO5)=O)=O)=O)CC1 |
Summary
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species ( ROS ) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei . Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC 50 of 1.2 ng/mL [1] [2] [3] [4] [5] .
In Vitro
Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the
apoptosis
of A549 cells
[1]
.
Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 and H1793 cells with IC
50
values of approximately 10 nM and 20 nM after 48 h of treatment, respectively
[1]
.
Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC
50
of 300 nM for HCT 116 and SW-620 cell proliferation
[2]
.
Verrucarin J (0, 10, 20 nM, 48 hours) inhibits
cancer
stem cell (CSC) self-renewal pathways Wnt1/β-catenin and Notch1 and down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 and CD133) of A549 cells
[1]
.
Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against
Candida albicans
and
Mucor miehei
[3]
.
Verrucarin J reduces JUNV yield more than 2 log units and has a similar effect against the
arenavirus
Tacaribe
[4]
.
Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50%
(CC
50
) of 8.2 ng/mL
[4]
.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Verrucarin J Related Antibodies
- ALIX Antibody
- CNPase Antibody
- COX IV Antibody
- COX2 Antibody
- Cyclin B1 Antibody (YA486)
- Cyclin D1 Antibody (YA485)
- Cytochrome C Antibody
- E-Cadherin Antibody (YA778)
- E-Cadherin Antibody (YA470)
- Fatty Acid Synthase Antibody
- FosB Antibody
- GAPDH Antibody
- GFAP Antibody (YA755)
- GFAP Antibody (YA416)
- GFP Antibody
- FKBP52 Antibody
- Cleaved-PARP1 Antibody
- c-Myc Antibody
- Toll-Like Receptor 3 Antibody (YA659)
- Catalase Antibody (YA552)
- COX2/Cyclooxygenase 2 Antibody
- Ctip2 Antibody
- Cyclin A2 Antibody
- DYKDDDDK Tag (FLAG) Antibody
- EEA1 Antibody
- EpCAM Antibody (YA772)
- FIP200 Antibody
- Lamin A/C Antibody
- Lamin B1 Antibody
- p53 Antibody (YA250)
In Vivo
Verrucarin J (0.5 mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model
[2]
.
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent
anticancer
drug and suppresses tumor growth and metastasis
[5]
.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts [2] |
| Dosage: | 0.5 mg/kg body weight |
| Administration: | i.p. for 4 weeks |
| Result: | Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors. |
| Animal Model: | Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts [5] |
| Dosage: | 0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate) |
| Administration: | i.p. for three weeks after 10 days of injection of A2780 cells |
| Result: |
Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg.
Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg. Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg. In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Udoh K, et al. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J. Stem Cell Rev Rep. 2019 Aug;15(4):601-611.
- [2] Pal D, et al. Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer. Cell Death Dis. 2018 Jul 23;9(8):798.
- [3] Mondol MA, et al. Macrocyclic Trichothecenes from Myrothecium roridum Strain M10 with Motility Inhibitory and Zoosporicidal Activities against Phytophthora nicotianae. J Agric Food Chem. 2015 Oct 14;63(40):8777-86.
- [4] García CC, et al, Damonte EB. Evaluation of the antiviral activity against Junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia. Planta Med. 2002 Mar;68(3):209-12.
- [5] Carter K, et al. Verrucarin J inhibits ovarian cancer and targets cancer stem cells. Oncotarget. 2017 Oct 6;8(54):92743-92756.
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