[CAS NO. ] GRK2i TFA

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PRODUCTS SPECIFICATIONS

Catelog

HY-P1396A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	3598.10
Molecular Formula	C152H257F3N50O43S
SMILES	-

For research use only. We do not sell to patients.

Summary

GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 100 mg/mL ( 27.79 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.2779 mL	1.3896 mL	2.7792 mL
5 mM	0.0556 mL	0.2779 mL	0.5558 mL
10 mM	0.0278 mL	0.1390 mL	0.2779 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 50 mg/mL (13.90 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Jorge A Sierra-Fonseca, et al. Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci. 2014 Dec 31;15:132.